Lamiridosins, hepatitis C virus entry inhibitors from Lamium album

Hongjie ZHANG; Katharina Rothwangl; Andrew D. Mesecar; Ali Sabahi; Lijun Rong; Harry H.S. Fong

doi:10.1021/np900549e

Lamiridosins, hepatitis C virus entry inhibitors from Lamium album

Hongjie ZHANG^*, Katharina Rothwangl, Andrew D. Mesecar, Ali Sabahi, Lijun Rong, Harry H.S. Fong

^*Corresponding author for this work

School of Chinese Medicine

Research output: Contribution to journal › Journal article › peer-review

55 Citations (Scopus)

Abstract

Phytochemical study of the aqueous extract of the flowering tops of Lamium album led to identification of the antiviral iridoid isomers lamiridosins A and B (1, 2). These compounds were found to significantly inhibit hepatitis C virus entry (IC₅₀ 2.31 μM) in vitro. Studies of 14 iridoid analogues showed that, while the parent iridoid glucosides demonstrated no anti-HCV entry activity, the aglycones of shanzhiside methyl ester (4), loganin (5), loganic acid (6), geniposide (10), verbenalin (12), eurostoside (15), and picroside II (17) exhibited significant anti-HCV entry and anti-infectivity activities.

Original language	English
Pages (from-to)	2158-2162
Number of pages	5
Journal	Journal of Natural Products
Volume	72
Issue number	12
DOIs	https://doi.org/10.1021/np900549e
Publication status	Published - 28 Dec 2009

Scopus Subject Areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Lamiridosins, hepatitis C virus entry inhibitors from Lamium album",

abstract = "Phytochemical study of the aqueous extract of the flowering tops of Lamium album led to identification of the antiviral iridoid isomers lamiridosins A and B (1, 2). These compounds were found to significantly inhibit hepatitis C virus entry (IC50 2.31 μM) in vitro. Studies of 14 iridoid analogues showed that, while the parent iridoid glucosides demonstrated no anti-HCV entry activity, the aglycones of shanzhiside methyl ester (4), loganin (5), loganic acid (6), geniposide (10), verbenalin (12), eurostoside (15), and picroside II (17) exhibited significant anti-HCV entry and anti-infectivity activities.",

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AU - ZHANG, Hongjie

AU - Rothwangl, Katharina

AU - Mesecar, Andrew D.

AU - Sabahi, Ali

AU - Rong, Lijun

AU - Fong, Harry H.S.

PY - 2009/12/28

Y1 - 2009/12/28

N2 - Phytochemical study of the aqueous extract of the flowering tops of Lamium album led to identification of the antiviral iridoid isomers lamiridosins A and B (1, 2). These compounds were found to significantly inhibit hepatitis C virus entry (IC50 2.31 μM) in vitro. Studies of 14 iridoid analogues showed that, while the parent iridoid glucosides demonstrated no anti-HCV entry activity, the aglycones of shanzhiside methyl ester (4), loganin (5), loganic acid (6), geniposide (10), verbenalin (12), eurostoside (15), and picroside II (17) exhibited significant anti-HCV entry and anti-infectivity activities.

AB - Phytochemical study of the aqueous extract of the flowering tops of Lamium album led to identification of the antiviral iridoid isomers lamiridosins A and B (1, 2). These compounds were found to significantly inhibit hepatitis C virus entry (IC50 2.31 μM) in vitro. Studies of 14 iridoid analogues showed that, while the parent iridoid glucosides demonstrated no anti-HCV entry activity, the aglycones of shanzhiside methyl ester (4), loganin (5), loganic acid (6), geniposide (10), verbenalin (12), eurostoside (15), and picroside II (17) exhibited significant anti-HCV entry and anti-infectivity activities.

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Lamiridosins, hepatitis C virus entry inhibitors from Lamium album

Abstract

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