Lamiridosins, hepatitis C virus entry inhibitors from Lamium album

Hongjie ZHANG*, Katharina Rothwangl, Andrew D. Mesecar, Ali Sabahi, Lijun Rong, Harry H.S. Fong

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

Phytochemical study of the aqueous extract of the flowering tops of Lamium album led to identification of the antiviral iridoid isomers lamiridosins A and B (1, 2). These compounds were found to significantly inhibit hepatitis C virus entry (IC50 2.31 μM) in vitro. Studies of 14 iridoid analogues showed that, while the parent iridoid glucosides demonstrated no anti-HCV entry activity, the aglycones of shanzhiside methyl ester (4), loganin (5), loganic acid (6), geniposide (10), verbenalin (12), eurostoside (15), and picroside II (17) exhibited significant anti-HCV entry and anti-infectivity activities.

Original languageEnglish
Pages (from-to)2158-2162
Number of pages5
JournalJournal of Natural Products
Volume72
Issue number12
DOIs
Publication statusPublished - 28 Dec 2009

Scopus Subject Areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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