Lamiridosins, hepatitis C virus entry inhibitors from Lamium album

Hongjie ZHANG; Katharina Rothwangl; Andrew D. Mesecar; Ali Sabahi; Lijun Rong; Harry H.S. Fong

doi:10.1021/np900549e

Lamiridosins, hepatitis C virus entry inhibitors from Lamium album

Hongjie ZHANG^*, Katharina Rothwangl, Andrew D. Mesecar, Ali Sabahi, Lijun Rong, Harry H.S. Fong

^*Corresponding author for this work

School of Chinese Medicine

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

Phytochemical study of the aqueous extract of the flowering tops of Lamium album led to identification of the antiviral iridoid isomers lamiridosins A and B (1, 2). These compounds were found to significantly inhibit hepatitis C virus entry (IC₅₀ 2.31 μM) in vitro. Studies of 14 iridoid analogues showed that, while the parent iridoid glucosides demonstrated no anti-HCV entry activity, the aglycones of shanzhiside methyl ester (4), loganin (5), loganic acid (6), geniposide (10), verbenalin (12), eurostoside (15), and picroside II (17) exhibited significant anti-HCV entry and anti-infectivity activities.

Original language	English
Pages (from-to)	2158-2162
Number of pages	5
Journal	Journal of Natural Products
Volume	72
Issue number	12
DOIs	https://doi.org/10.1021/np900549e
Publication status	Published - 28 Dec 2009

Scopus Subject Areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1021/np900549e

Cite this

@article{2d57a517ade246d28b2cfdfc11485ba3,

title = "Lamiridosins, hepatitis C virus entry inhibitors from Lamium album",

abstract = "Phytochemical study of the aqueous extract of the flowering tops of Lamium album led to identification of the antiviral iridoid isomers lamiridosins A and B (1, 2). These compounds were found to significantly inhibit hepatitis C virus entry (IC50 2.31 μM) in vitro. Studies of 14 iridoid analogues showed that, while the parent iridoid glucosides demonstrated no anti-HCV entry activity, the aglycones of shanzhiside methyl ester (4), loganin (5), loganic acid (6), geniposide (10), verbenalin (12), eurostoside (15), and picroside II (17) exhibited significant anti-HCV entry and anti-infectivity activities.",

author = "Hongjie ZHANG and Katharina Rothwangl and Mesecar, {Andrew D.} and Ali Sabahi and Lijun Rong and Fong, {Harry H.S.}",

year = "2009",

month = dec,

day = "28",

doi = "10.1021/np900549e",

language = "English",

volume = "72",

pages = "2158--2162",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "12",

}

TY - JOUR

T1 - Lamiridosins, hepatitis C virus entry inhibitors from Lamium album

AU - ZHANG, Hongjie

AU - Rothwangl, Katharina

AU - Mesecar, Andrew D.

AU - Sabahi, Ali

AU - Rong, Lijun

AU - Fong, Harry H.S.

PY - 2009/12/28

Y1 - 2009/12/28

N2 - Phytochemical study of the aqueous extract of the flowering tops of Lamium album led to identification of the antiviral iridoid isomers lamiridosins A and B (1, 2). These compounds were found to significantly inhibit hepatitis C virus entry (IC50 2.31 μM) in vitro. Studies of 14 iridoid analogues showed that, while the parent iridoid glucosides demonstrated no anti-HCV entry activity, the aglycones of shanzhiside methyl ester (4), loganin (5), loganic acid (6), geniposide (10), verbenalin (12), eurostoside (15), and picroside II (17) exhibited significant anti-HCV entry and anti-infectivity activities.

AB - Phytochemical study of the aqueous extract of the flowering tops of Lamium album led to identification of the antiviral iridoid isomers lamiridosins A and B (1, 2). These compounds were found to significantly inhibit hepatitis C virus entry (IC50 2.31 μM) in vitro. Studies of 14 iridoid analogues showed that, while the parent iridoid glucosides demonstrated no anti-HCV entry activity, the aglycones of shanzhiside methyl ester (4), loganin (5), loganic acid (6), geniposide (10), verbenalin (12), eurostoside (15), and picroside II (17) exhibited significant anti-HCV entry and anti-infectivity activities.

UR - http://www.scopus.com/inward/record.url?scp=74049131015&partnerID=8YFLogxK

U2 - 10.1021/np900549e

DO - 10.1021/np900549e

M3 - Article

C2 - 19904996

AN - SCOPUS:74049131015

SN - 0163-3864

VL - 72

SP - 2158

EP - 2162

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 12

ER -

Lamiridosins, hepatitis C virus entry inhibitors from Lamium album

Abstract

Scopus Subject Areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this