TY - JOUR
T1 - Lamiridosins, hepatitis C virus entry inhibitors from Lamium album
AU - Zhang, Hongjie
AU - Rothwangl, Katharina
AU - Mesecar, Andrew D.
AU - Sabahi, Ali
AU - Rong, Lijun
AU - Fong, Harry H.S.
N1 - Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2009/12/28
Y1 - 2009/12/28
N2 - Phytochemical study of the aqueous extract of the flowering tops of Lamium album led to identification of the antiviral iridoid isomers lamiridosins A and B (1, 2). These compounds were found to significantly inhibit hepatitis C virus entry (IC50 2.31 μM) in vitro. Studies of 14 iridoid analogues showed that, while the parent iridoid glucosides demonstrated no anti-HCV entry activity, the aglycones of shanzhiside methyl ester (4), loganin (5), loganic acid (6), geniposide (10), verbenalin (12), eurostoside (15), and picroside II (17) exhibited significant anti-HCV entry and anti-infectivity activities.
AB - Phytochemical study of the aqueous extract of the flowering tops of Lamium album led to identification of the antiviral iridoid isomers lamiridosins A and B (1, 2). These compounds were found to significantly inhibit hepatitis C virus entry (IC50 2.31 μM) in vitro. Studies of 14 iridoid analogues showed that, while the parent iridoid glucosides demonstrated no anti-HCV entry activity, the aglycones of shanzhiside methyl ester (4), loganin (5), loganic acid (6), geniposide (10), verbenalin (12), eurostoside (15), and picroside II (17) exhibited significant anti-HCV entry and anti-infectivity activities.
UR - http://www.scopus.com/inward/record.url?scp=74049131015&partnerID=8YFLogxK
U2 - 10.1021/np900549e
DO - 10.1021/np900549e
M3 - Journal article
C2 - 19904996
AN - SCOPUS:74049131015
SN - 0163-3864
VL - 72
SP - 2158
EP - 2162
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 12
ER -
