Label-free sensing of pH and silver nanoparticles using an OR logic gate

Edmond Dik Lung MA*, Hong Zhang He, Victor Pui Yan Ma, Daniel Shiu Hin Chan, Ka Ho Leung, Hai Jing Zhong, Lihua Lu, Jean Louis Mergny, Chung Hang Leung

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

30 Citations (Scopus)


Many natural phenomena are associated with the presence of two or more separate variables. We report here an "OR" DNA logic gate based on a luminescent platinum(II) switch-on probe for silver nanoparticles and pH, both of which may be considered putative indicators of pollution. The modulation of metal complex/double-stranded DNA complex phosphorescence by Ag+ and H+ was used to construct a simple, rapid and label-free method for the label-free detection of pH and nanomolar Ag+ ions and nanoparticles in aqueous solutions with high selectivity.

Original languageEnglish
Pages (from-to)78-83
Number of pages6
JournalAnalytica Chimica Acta
Publication statusPublished - 6 Jul 2012

Scopus Subject Areas

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy

User-Defined Keywords

  • Label-free detection
  • Logic gate
  • Luminescent probe
  • Platinum(II) complex
  • Silver nanoparticle


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