TY - JOUR
T1 - Label-free probes using DNA-templated silver nanoclusters as versatile reporters
AU - Guo, Yahui
AU - Pan, Xinyue
AU - Zhang, Wenya
AU - Hu, Zhigang
AU - Wong, Ka Wang
AU - He, Zhike
AU - Li, Hung Wing
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China (No. 31601552 ), the National Key Research and Development Program of China (No. 2017YFC1601704 , 2018YFC1602300 ), the National First-class Discipline Program of Food Science and Technology ( JUFSTR20180509 ) and the “Hong Kong Scholar” program . Appendix
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2020/2/15
Y1 - 2020/2/15
N2 - DNA-templated silver nanoclusters (DNA-AgNCs) have demonstrated pervasive applications in analytical chemistry recently. As a way of signal output in DNA-based detection methods, DNA-AgNCs have prominent advantages: first, the recognition and synthesizing sequences are naturally integrated in one DNA probe without any chemical modification or connection; second, the emissive wavelength of DNA-AgNCs can be adjusted in a wide range by employing different sequences; third, DNA-AgNCs can be utilized for producing not only fluorescence, also electrochemiluminescence and electrochemical signals. Besides, they also show potential applications for cell imaging, and are considered to be one of the most ideal nanomaterials for in-vivo imaging due to their ultra-small particle size. In this review, a brief and comprehensive introduction of DNA-AgNCs is firstly given, then label-free probes using DNA-AgNCs are classified and summarized, lastly concluding perspectives are provided on the defects and application potentials.
AB - DNA-templated silver nanoclusters (DNA-AgNCs) have demonstrated pervasive applications in analytical chemistry recently. As a way of signal output in DNA-based detection methods, DNA-AgNCs have prominent advantages: first, the recognition and synthesizing sequences are naturally integrated in one DNA probe without any chemical modification or connection; second, the emissive wavelength of DNA-AgNCs can be adjusted in a wide range by employing different sequences; third, DNA-AgNCs can be utilized for producing not only fluorescence, also electrochemiluminescence and electrochemical signals. Besides, they also show potential applications for cell imaging, and are considered to be one of the most ideal nanomaterials for in-vivo imaging due to their ultra-small particle size. In this review, a brief and comprehensive introduction of DNA-AgNCs is firstly given, then label-free probes using DNA-AgNCs are classified and summarized, lastly concluding perspectives are provided on the defects and application potentials.
KW - Biosensor
KW - DNA silver nanoclusters
KW - Electrochemiluminescence
KW - Fluorescence
KW - Label free
UR - http://www.scopus.com/inward/record.url?scp=85076528670&partnerID=8YFLogxK
U2 - 10.1016/j.bios.2019.111926
DO - 10.1016/j.bios.2019.111926
M3 - Review article
C2 - 31929081
AN - SCOPUS:85076528670
SN - 0956-5663
VL - 150
JO - Biosensors and Bioelectronics
JF - Biosensors and Bioelectronics
M1 - 111926
ER -