Label-free luminescent switch-on probe for ochratoxin a detection using a G-quadruplex-selective iridium(III) complex

Lihua Lu; Modi Wang; Li Juan Liu; Chung Hang Leung; Edmond Dik Lung MA

doi:10.1021/acsami.5b01702

Label-free luminescent switch-on probe for ochratoxin a detection using a G-quadruplex-selective iridium(III) complex

Lihua Lu, Modi Wang, Li Juan Liu, Chung Hang Leung^*, Edmond Dik Lung MA

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

A library of six luminescent Ir(III) complexes were synthesized and studied for their capacity to function as probes for G-quadruplex DNA. The novel Ir(III) complex 1 was discovered to be selective for G-quadruplex structures and was subsequently used for the construction of a label-free G-quadruplex-based ochratoxin A (OTA) sensing platform in aqueous solution. The assay exhibited linearity for OTA in the range of 0 to 60 nM (R² = 0.9933), and the limit of detection for OTA was 5 nM. Furthermore, this assay was highly selective for OTA over its structurally related analogues.

Original language	English
Pages (from-to)	8313-8318
Number of pages	6
Journal	ACS applied materials & interfaces
Volume	7
Issue number	15
DOIs	https://doi.org/10.1021/acsami.5b01702
Publication status	Published - 22 Apr 2015

Scopus Subject Areas

Materials Science(all)

User-Defined Keywords

G-quadruplex
iridium(III) complex
label-free
luminescent
ochratoxin A

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10.1021/acsami.5b01702

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abstract = "A library of six luminescent Ir(III) complexes were synthesized and studied for their capacity to function as probes for G-quadruplex DNA. The novel Ir(III) complex 1 was discovered to be selective for G-quadruplex structures and was subsequently used for the construction of a label-free G-quadruplex-based ochratoxin A (OTA) sensing platform in aqueous solution. The assay exhibited linearity for OTA in the range of 0 to 60 nM (R2 = 0.9933), and the limit of detection for OTA was 5 nM. Furthermore, this assay was highly selective for OTA over its structurally related analogues.",

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AU - Leung, Chung Hang

AU - MA, Edmond Dik Lung

PY - 2015/4/22

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AB - A library of six luminescent Ir(III) complexes were synthesized and studied for their capacity to function as probes for G-quadruplex DNA. The novel Ir(III) complex 1 was discovered to be selective for G-quadruplex structures and was subsequently used for the construction of a label-free G-quadruplex-based ochratoxin A (OTA) sensing platform in aqueous solution. The assay exhibited linearity for OTA in the range of 0 to 60 nM (R2 = 0.9933), and the limit of detection for OTA was 5 nM. Furthermore, this assay was highly selective for OTA over its structurally related analogues.

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Label-free luminescent switch-on probe for ochratoxin a detection using a G-quadruplex-selective iridium(III) complex

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