Abstract
A library of six luminescent Ir(III) complexes were synthesized and studied for their capacity to function as probes for G-quadruplex DNA. The novel Ir(III) complex 1 was discovered to be selective for G-quadruplex structures and was subsequently used for the construction of a label-free G-quadruplex-based ochratoxin A (OTA) sensing platform in aqueous solution. The assay exhibited linearity for OTA in the range of 0 to 60 nM (R2 = 0.9933), and the limit of detection for OTA was 5 nM. Furthermore, this assay was highly selective for OTA over its structurally related analogues.
Original language | English |
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Pages (from-to) | 8313-8318 |
Number of pages | 6 |
Journal | ACS applied materials & interfaces |
Volume | 7 |
Issue number | 15 |
DOIs | |
Publication status | Published - 22 Apr 2015 |
Scopus Subject Areas
- Materials Science(all)
User-Defined Keywords
- G-quadruplex
- iridium(III) complex
- label-free
- luminescent
- ochratoxin A