@article{82bc9e4d345f4c55971ffea153ccc45f,
title = "Label-free luminescent switch-on probe for ochratoxin a detection using a G-quadruplex-selective iridium(III) complex",
abstract = "A library of six luminescent Ir(III) complexes were synthesized and studied for their capacity to function as probes for G-quadruplex DNA. The novel Ir(III) complex 1 was discovered to be selective for G-quadruplex structures and was subsequently used for the construction of a label-free G-quadruplex-based ochratoxin A (OTA) sensing platform in aqueous solution. The assay exhibited linearity for OTA in the range of 0 to 60 nM (R2 = 0.9933), and the limit of detection for OTA was 5 nM. Furthermore, this assay was highly selective for OTA over its structurally related analogues.",
keywords = "G-quadruplex, iridium(III) complex, label-free, luminescent, ochratoxin A",
author = "Lihua Lu and Modi Wang and Liu, {Li Juan} and Leung, {Chung Hang} and Ma, {Dik Lung}",
note = "Funding information: This work is supported by Hong Kong Baptist University (FRG2/13-14/008 and FRG2/14-15/004), Centre for Cancer and Inflammation Research, School of Chinese Medicine (CCIR-SCM, HKBU), the Health and Medical Research Fund (HMRF/13121482 and HMRF/14130522), the Research Grants Council (HKBU/201811, HKBU/204612, and HKBU/201913), the French National Research Agency/Research Grants Council Joint Research Scheme (A-HKBU201/12), State Key Laboratory of Environmental and Biological Analysis Research Grant (SKLP-14-15-P001), the State Key Laboratory of Synthetic Chemistry, the Science and Technology Development Fund, Macao SAR (103/2012/A3), and the University of Macau (MYRG091(Y3-L2)-ICMS12-LCH, MYRG2015-00137-ICMS-QRCM, and MRG023/LCH/2013/ICMS). Publisher copyright: {\textcopyright} 2015 American Chemical Society",
year = "2015",
month = apr,
day = "22",
doi = "10.1021/acsami.5b01702",
language = "English",
volume = "7",
pages = "8313--8318",
journal = "ACS applied materials & interfaces",
issn = "1944-8244",
publisher = "American Chemical Society",
number = "15",
}