Label-free luminescent switch-on probe for ochratoxin a detection using a G-quadruplex-selective iridium(III) complex

Lihua Lu, Modi Wang, Li Juan Liu, Chung Hang Leung*, Edmond Dik Lung MA

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

A library of six luminescent Ir(III) complexes were synthesized and studied for their capacity to function as probes for G-quadruplex DNA. The novel Ir(III) complex 1 was discovered to be selective for G-quadruplex structures and was subsequently used for the construction of a label-free G-quadruplex-based ochratoxin A (OTA) sensing platform in aqueous solution. The assay exhibited linearity for OTA in the range of 0 to 60 nM (R2 = 0.9933), and the limit of detection for OTA was 5 nM. Furthermore, this assay was highly selective for OTA over its structurally related analogues.

Original languageEnglish
Pages (from-to)8313-8318
Number of pages6
JournalACS applied materials & interfaces
Volume7
Issue number15
DOIs
Publication statusPublished - 22 Apr 2015

Scopus Subject Areas

  • Materials Science(all)

User-Defined Keywords

  • G-quadruplex
  • iridium(III) complex
  • label-free
  • luminescent
  • ochratoxin A

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