@article{d2f4f34a1f0d4f15a4678f3d7174eda1,
title = "Label-free luminescence switch-on detection of T4 polynucleotide kinase activity using a G-quadruplex-selective probe",
abstract = "A label-free, oligonucleotide-based, switch-on luminescence detection method for T4 polynucleotide kinase activity has been developed using a novel G-quadruplex-selective luminescent Ir(III) complex probe. The application of the assay for screening potential T4 PNK inhibitors is also demonstrated. To our knowledge, this is the first metal-based assay for PNK activity.",
author = "He, \{Hong Zhang\} and Leung, \{Ka Ho\} and Wei Wang and Chan, \{Daniel Shiu Hin\} and Leung, \{Chung Hang\} and Ma, \{Dik Lung\}",
note = "This work is supported by Hong Kong Baptist University (FRG2/12-13/021), Centre for Cancer and Inflammation Research, School of Chinese Medicine (CCIR-SCM, HKBU), the Health and Medical Research Fund (HMRF/13121482), the Research Grants Council (HKBU/201811, HKBU/204612, and HKBU/201913), the French National Research Agency/Research Grants Council Joint Research Scheme (A-HKBU201/12), the Science and Technology Development Fund, Macao SAR (103/2012/A3, 001/2012/A) and the University of Macau (MYRG091(Y2-L2)-ICMS12-LCH and MYRG121(Y2-L2)-ICMS12-LCH). ",
year = "2014",
month = apr,
day = "22",
doi = "10.1039/c3cc47444e",
language = "English",
volume = "50",
pages = "5313--5315",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "40",
}