Abstract
A highly efficient kinetic resolution of racemic 2-substituted 1,2-dihydroquinolines via Rh-catalyzed asymmetric hydroarylation has been described for the first time. A variety of arylboronic acids coupled with 2-substituted 1,2-dihydroquinolines under mild reaction condition. The transformations into the enantio-enriched 2,3-diaryl-tetrahydroquinolines as well as the recovered chiral 2-aryl-dihydroquinolines were obtained with high yields and excellent enantioselectivities (86%—99% ee, s factor up to 1057).
Original language | English |
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Pages (from-to) | 1606-1610 |
Number of pages | 5 |
Journal | Chinese Journal of Chemistry |
Volume | 39 |
Issue number | 6 |
Early online date | 14 Feb 2021 |
DOIs | |
Publication status | Published - Jun 2021 |
Scopus Subject Areas
- General Chemistry
User-Defined Keywords
- Asymmetric catalysis
- Hydroarylation
- Kinetic resolution
- Tetrahydroquinoline
- Transition metal