Kinetic Resolution and Dynamic Kinetic Resolution of Chromene by Rhodium‐Catalyzed Asymmetric Hydroarylation

Qingjing Yang, Yanbo Wang, Shihui Luo, Jun (Joelle) Wang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A highly efficient kinetic resolution and dynamic kinetic resolution of chromene is reported for the first time and they procced by a rhodium-catalyzed asymmetric hydroarylation pathway. This new approach offers versatile access to various chiral 2,3-diaryl-chromanes containing vicinal stereogenic centers, as well as the recovered chiral flavenes, in high yields with excellent ee values (s factor up to 532). Particularly noteworthy is that this strategy can be further extended to the establishment of a dynamic version of the kinetic resolution of chromene acetals and allows complete access to chiral isoflavanes and α-aryl hydrocoumarins.

Original languageEnglish
Pages (from-to)5343-5347
JournalAngewandte Chemie. International Edition
Volume58
Issue number16
DOIs
Publication statusPublished - 8 Apr 2019

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