TY - JOUR
T1 - Joint Effects of Multiple UV Filters on Zebrafish Embryo Development
AU - Li, Adela Jing
AU - Law, Japhet Cheuk Fung
AU - Chow, Chi Hang
AU - Huang, Yanran
AU - Li, Kaibin
AU - Leung, Kelvin Sze Yin
N1 - Funding Information:
This work was supported by funding from the Science, Technology and Innovation Commission of Shenzhen (JCYJ20150630164505506) and the National Science Foundation of China (31500441). K.S.-Y.L. also is thankful for the grants from the interinstitutional Collaborative Research Scheme (RC-ICRS/16-17/02B) and Interdisciplinary Research Matching Scheme (RC-IRMS/16-17/01A), Hong Kong Baptist University. J.C.-F.L., C.-H.C., and Y.H. gratefully acknowledge their receipt of postgraduate studentships from the University Grants Committee.
Publisher copyright:
© 2018 American Chemical Society
PY - 2018/8/21
Y1 - 2018/8/21
N2 - The widespread use of UV filters has resulted in significant amounts of these chemicals appearing not only in the environment but also in organisms. This study first assessed the levels of nine UV filters in waters along the coast of Shenzhen, China, in tapwater, and in a nearby reservoir. UV filters were found to be high, in both winter and summer at most locations. Then, using zebrafish as a model, the influence of a UV filter mixture after dietary and aqueous exposure was assessed. After exposing artemia to three dominant UV filters at two levels and then feeding these artemia to zebrafish adults, concentrations in both were up to 4 times higher when exposed to the mixtures than when exposed to only a single UV filter. A short-term 25-day dietary exposure to the zebrafish adults did not appear to significantly influence early life stage development of the second generation; however, relatively long exposure over 47 days had significant adverse effects on embryo development. Aqueous exposure of fish embryos to mixtures of the three UV filters demonstrated a general trend of decreased heart/hatching rate as doses increased, coupled with significant changes in activities of catalase and malate dehydrogenase.
AB - The widespread use of UV filters has resulted in significant amounts of these chemicals appearing not only in the environment but also in organisms. This study first assessed the levels of nine UV filters in waters along the coast of Shenzhen, China, in tapwater, and in a nearby reservoir. UV filters were found to be high, in both winter and summer at most locations. Then, using zebrafish as a model, the influence of a UV filter mixture after dietary and aqueous exposure was assessed. After exposing artemia to three dominant UV filters at two levels and then feeding these artemia to zebrafish adults, concentrations in both were up to 4 times higher when exposed to the mixtures than when exposed to only a single UV filter. A short-term 25-day dietary exposure to the zebrafish adults did not appear to significantly influence early life stage development of the second generation; however, relatively long exposure over 47 days had significant adverse effects on embryo development. Aqueous exposure of fish embryos to mixtures of the three UV filters demonstrated a general trend of decreased heart/hatching rate as doses increased, coupled with significant changes in activities of catalase and malate dehydrogenase.
UR - http://www.scopus.com/inward/record.url?scp=85052091598&partnerID=8YFLogxK
U2 - 10.1021/acs.est.8b02418
DO - 10.1021/acs.est.8b02418
M3 - Journal article
C2 - 30066570
AN - SCOPUS:85052091598
SN - 0013-936X
VL - 52
SP - 9460
EP - 9467
JO - Environmental Science and Technology
JF - Environmental Science and Technology
IS - 16
ER -
