JCM-16021, a Chinese herbal formula, attenuated visceral hyperalgesia in TNBS-induced postinflammatory irritable bowel syndrome through reducing colonic EC cell hyperplasia and serotonin availability in rats

Hong Yan Qin; Haitao XIAO; Fung Ping LEUNG; Zhijun YANG; Justin C.Y. Wu; Joseph J.Y. Sung; Hong Xi Xu; Xu Dong Tong; Zhaoxiang BIAN

doi:10.1155/2012/239638

JCM-16021, a Chinese herbal formula, attenuated visceral hyperalgesia in TNBS-induced postinflammatory irritable bowel syndrome through reducing colonic EC cell hyperplasia and serotonin availability in rats

Hong Yan Qin, Haitao XIAO, Fung Ping LEUNG, Zhijun YANG, Justin C.Y. Wu, Joseph J.Y. Sung, Hong Xi Xu, Xu Dong Tong, Zhaoxiang BIAN^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

17 Citations (Scopus)

Abstract

The present study aimed to investigate the analgesic effect of JCM-16021, a revised traditional Chinese herbal formula, on postinflammatory irritable bowel syndrome (PI-IBS) in rats. The trinitrobenzene sulfonic (TNBS) acid-induced PI-IBS model rats were orally administrated with different doses of JCM-16021 (1.2, 2.4, and 4.8g/kg/d) for 14 consecutive days. The results showed that JCM-16021 treatment dose-dependently attenuated visceral hyperalgesia in PI-IBS rats. Further, the colonic enterochromaffin (EC) cell number, serotonin (5-HT) content, tryptophan hydroxylase expression, and mechanical-stimuli-induced 5-HT release were significantly ameliorated. Moreover, the decreased levels of mucosal cytokines in PI-IBS, especially the helper T-cell type 1- (Th1-) related cytokine TNF-α, were also elevated after JCM-16021 treatment. These data demonstrate that the analgesic effect of JCM-16021 on TNBS-induced PI-IBS rats may be medicated via reducing colonic EC cell hyperplasia and 5-HT availability.

Original language	English
Article number	239638
Journal	Evidence-based Complementary and Alternative Medicine
Volume	2012
DOIs	https://doi.org/10.1155/2012/239638
Publication status	Published - 2012

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Complementary and alternative medicine

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Qin, H. Y., XIAO, H., LEUNG, F. P., YANG, Z., Wu, J. C. Y., Sung, J. J. Y., Xu, H. X., Tong, X. D., & BIAN, Z. (2012). JCM-16021, a Chinese herbal formula, attenuated visceral hyperalgesia in TNBS-induced postinflammatory irritable bowel syndrome through reducing colonic EC cell hyperplasia and serotonin availability in rats. Evidence-based Complementary and Alternative Medicine, 2012, Article 239638. https://doi.org/10.1155/2012/239638

@article{fda0c6f510dd486cb2bd2eebee7da7a6,

title = "JCM-16021, a Chinese herbal formula, attenuated visceral hyperalgesia in TNBS-induced postinflammatory irritable bowel syndrome through reducing colonic EC cell hyperplasia and serotonin availability in rats",

abstract = "The present study aimed to investigate the analgesic effect of JCM-16021, a revised traditional Chinese herbal formula, on postinflammatory irritable bowel syndrome (PI-IBS) in rats. The trinitrobenzene sulfonic (TNBS) acid-induced PI-IBS model rats were orally administrated with different doses of JCM-16021 (1.2, 2.4, and 4.8g/kg/d) for 14 consecutive days. The results showed that JCM-16021 treatment dose-dependently attenuated visceral hyperalgesia in PI-IBS rats. Further, the colonic enterochromaffin (EC) cell number, serotonin (5-HT) content, tryptophan hydroxylase expression, and mechanical-stimuli-induced 5-HT release were significantly ameliorated. Moreover, the decreased levels of mucosal cytokines in PI-IBS, especially the helper T-cell type 1- (Th1-) related cytokine TNF-α, were also elevated after JCM-16021 treatment. These data demonstrate that the analgesic effect of JCM-16021 on TNBS-induced PI-IBS rats may be medicated via reducing colonic EC cell hyperplasia and 5-HT availability.",

author = "Qin, {Hong Yan} and Haitao XIAO and LEUNG, {Fung Ping} and Zhijun YANG and Wu, {Justin C.Y.} and Sung, {Joseph J.Y.} and Xu, {Hong Xi} and Tong, {Xu Dong} and Zhaoxiang BIAN",

year = "2012",

doi = "10.1155/2012/239638",

language = "English",

volume = "2012",

journal = "Evidence-based Complementary and Alternative Medicine",

issn = "1741-427X",

publisher = "Hindawi Publishing Corporation",

}

Qin, HY, XIAO, H, LEUNG, FP, YANG, Z, Wu, JCY, Sung, JJY, Xu, HX, Tong, XD & BIAN, Z 2012, 'JCM-16021, a Chinese herbal formula, attenuated visceral hyperalgesia in TNBS-induced postinflammatory irritable bowel syndrome through reducing colonic EC cell hyperplasia and serotonin availability in rats', Evidence-based Complementary and Alternative Medicine, vol. 2012, 239638. https://doi.org/10.1155/2012/239638

JCM-16021, a Chinese herbal formula, attenuated visceral hyperalgesia in TNBS-induced postinflammatory irritable bowel syndrome through reducing colonic EC cell hyperplasia and serotonin availability in rats. / Qin, Hong Yan; XIAO, Haitao; LEUNG, Fung Ping et al.
In: Evidence-based Complementary and Alternative Medicine, Vol. 2012, 239638, 2012.

Research output: Contribution to journal › Journal article › peer-review

TY - JOUR

T1 - JCM-16021, a Chinese herbal formula, attenuated visceral hyperalgesia in TNBS-induced postinflammatory irritable bowel syndrome through reducing colonic EC cell hyperplasia and serotonin availability in rats

AU - Qin, Hong Yan

AU - XIAO, Haitao

AU - LEUNG, Fung Ping

AU - YANG, Zhijun

AU - Wu, Justin C.Y.

AU - Sung, Joseph J.Y.

AU - Xu, Hong Xi

AU - Tong, Xu Dong

AU - BIAN, Zhaoxiang

PY - 2012

Y1 - 2012

N2 - The present study aimed to investigate the analgesic effect of JCM-16021, a revised traditional Chinese herbal formula, on postinflammatory irritable bowel syndrome (PI-IBS) in rats. The trinitrobenzene sulfonic (TNBS) acid-induced PI-IBS model rats were orally administrated with different doses of JCM-16021 (1.2, 2.4, and 4.8g/kg/d) for 14 consecutive days. The results showed that JCM-16021 treatment dose-dependently attenuated visceral hyperalgesia in PI-IBS rats. Further, the colonic enterochromaffin (EC) cell number, serotonin (5-HT) content, tryptophan hydroxylase expression, and mechanical-stimuli-induced 5-HT release were significantly ameliorated. Moreover, the decreased levels of mucosal cytokines in PI-IBS, especially the helper T-cell type 1- (Th1-) related cytokine TNF-α, were also elevated after JCM-16021 treatment. These data demonstrate that the analgesic effect of JCM-16021 on TNBS-induced PI-IBS rats may be medicated via reducing colonic EC cell hyperplasia and 5-HT availability.

AB - The present study aimed to investigate the analgesic effect of JCM-16021, a revised traditional Chinese herbal formula, on postinflammatory irritable bowel syndrome (PI-IBS) in rats. The trinitrobenzene sulfonic (TNBS) acid-induced PI-IBS model rats were orally administrated with different doses of JCM-16021 (1.2, 2.4, and 4.8g/kg/d) for 14 consecutive days. The results showed that JCM-16021 treatment dose-dependently attenuated visceral hyperalgesia in PI-IBS rats. Further, the colonic enterochromaffin (EC) cell number, serotonin (5-HT) content, tryptophan hydroxylase expression, and mechanical-stimuli-induced 5-HT release were significantly ameliorated. Moreover, the decreased levels of mucosal cytokines in PI-IBS, especially the helper T-cell type 1- (Th1-) related cytokine TNF-α, were also elevated after JCM-16021 treatment. These data demonstrate that the analgesic effect of JCM-16021 on TNBS-induced PI-IBS rats may be medicated via reducing colonic EC cell hyperplasia and 5-HT availability.

UR - http://www.scopus.com/inward/record.url?scp=84863672084&partnerID=8YFLogxK

U2 - 10.1155/2012/239638

DO - 10.1155/2012/239638

M3 - Journal article

AN - SCOPUS:84863672084

SN - 1741-427X

VL - 2012

JO - Evidence-based Complementary and Alternative Medicine

JF - Evidence-based Complementary and Alternative Medicine

M1 - 239638

ER -

JCM-16021, a Chinese herbal formula, attenuated visceral hyperalgesia in TNBS-induced postinflammatory irritable bowel syndrome through reducing colonic EC cell hyperplasia and serotonin availability in rats

Abstract

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