Janus and Amphiphilic MoS2 2D Sheets for Surface-Directed Orientational Assemblies toward Ex Vivo Dual Substrate Release

Jianing Wang, Shuqi Li, Lin Yang, Chak-Shing Kwan, Chengyi Xie, Kwan Yin Cheung, Raymond Wai-Yin Sun, Albert S C Chan, Zhifeng Huang, Zongwei Cai*, Tao Zeng*, Ken Cham-Fai Leung*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

1 Citation (Scopus)

Abstract

The two-dimensional (2-D) Janus and amphiphilic molybdenum disulfide (MoS2) nanosheet with opposite optical activities on each side (amphichiral) is synthesized by modifying sandwich-like bulk MoS2 with tannic acid and cholesterol through biphasic emulsion method. This new type of amphichiral Janus MoS2 nanosheet consists of a hydrophilic and positive optical activity tannic acid side as well as a hydrophobic and negative optical activity cholesterol side thereby characterized by circular dichroism. Surface-directed orientational differentiation assemblies are performed for the as-synthesized 2D material and are characterized by contact angle, infrared spectroscopy, X-ray photoelectron, and circular dichroism spectroscopies. The amphiphilic nature of the materials is demonstrated by the pre-organization of the nanosheets on either hydrophobic or hydrophilic surfaces, providing unprecedented properties of circular dichroism signal enhancement and wettability. Selective detachment of the surface organic groups (cholesterol and tannic acid fragments) is realized by matrix-assisted laser desorption/ionisation - time-of-flight (MALDI-TOF) mass spectrometry, and the dual substrate release in tissue is detected by ex vivo mass spectrometry imaging.

Original languageEnglish
Article number2400533
Number of pages11
JournalSmall Methods
Volume8
Issue number12
Early online date14 Jun 2024
DOIs
Publication statusPublished - 19 Dec 2024

Scopus Subject Areas

  • General Chemistry
  • General Materials Science

User-Defined Keywords

  • 2-D materials
  • janus materials
  • mass spectrometry imaging
  • molybdenum disulfide
  • surface-directed orientational self-assembly
  • molybdenum disulfide

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