Isolation of two bioactive ent-kauranoids from the leaves of Isodon xerophilus

Zhi Ying Weng, Sheng Xiong Huang, Ma Lin Li, Yue Qin Zeng, Quan Bin Han, Jose Luis Rios*, Han Dong Sun*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

10 Citations (Scopus)


Isodon xerophilus has been used as a herbal cold tea for the prevention and treatment of sore throat and inflammation in southernwestern China. A phytochemical study on the ethyl acetate (EtOAc) soluble fraction of I. xerophilus leaves led to the isolation of two new ent-kauranoids, xerophinoids A (1) and B (2), together with 14 known diterpenoids. The structures of xerophinoids A (1) and B (2) were illustrated using spectroscopic methods including 1D and 2D NMR analyses. To study their biological activities, the effects of xerophinoids A (1) and B (2) on nitrite production, tumor necrosis factor (TNF)-α and interleukin (IL)-1β were examined. In addition, xerophinoids A (1) and B (2) also exhibited potent cytotoxicity against several human tumor cell lines (IC50 < 11 μM), but they had no toxicity on human T-lymphocyte (C8166).

Original languageEnglish
Pages (from-to)6039-6043
Number of pages5
JournalJournal of Agricultural and Food Chemistry
Issue number15
Early online date27 Jun 2007
Publication statusPublished - 1 Jul 2007

Scopus Subject Areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

User-Defined Keywords

  • Anti-inflammation
  • Cytotoxicity
  • ent-kaurene diterpenoid
  • Herbal tea
  • Isodon xerophilus


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