Isolation of two bioactive ent-kauranoids from the leaves of Isodon xerophilus

Zhi Ying Weng; Sheng Xiong Huang; Ma Lin Li; Yue Qin Zeng; Quan Bin Han; Jose Luis Rios; Han Dong Sun

doi:10.1021/jf070734w

Isolation of two bioactive ent-kauranoids from the leaves of Isodon xerophilus

Zhi Ying Weng, Sheng Xiong Huang, Ma Lin Li, Yue Qin Zeng, Quan Bin Han, Jose Luis Rios^*, Han Dong Sun^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

12 Citations (Scopus)

Abstract

Isodon xerophilus has been used as a herbal cold tea for the prevention and treatment of sore throat and inflammation in southernwestern China. A phytochemical study on the ethyl acetate (EtOAc) soluble fraction of I. xerophilus leaves led to the isolation of two new ent-kauranoids, xerophinoids A (1) and B (2), together with 14 known diterpenoids. The structures of xerophinoids A (1) and B (2) were illustrated using spectroscopic methods including 1D and 2D NMR analyses. To study their biological activities, the effects of xerophinoids A (1) and B (2) on nitrite production, tumor necrosis factor (TNF)-α and interleukin (IL)-1β were examined. In addition, xerophinoids A (1) and B (2) also exhibited potent cytotoxicity against several human tumor cell lines (IC₅₀ < 11 μM), but they had no toxicity on human T-lymphocyte (C8166).

Original language	English
Pages (from-to)	6039-6043
Number of pages	5
Journal	Journal of Agricultural and Food Chemistry
Volume	55
Issue number	15
Early online date	27 Jun 2007
DOIs	https://doi.org/10.1021/jf070734w
Publication status	Published - 1 Jul 2007

Scopus Subject Areas

Chemistry(all)
Agricultural and Biological Sciences(all)

User-Defined Keywords

Anti-inflammation
Cytotoxicity
ent-kaurene diterpenoid
Herbal tea
Isodon xerophilus

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10.1021/jf070734w

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title = "Isolation of two bioactive ent-kauranoids from the leaves of Isodon xerophilus",

abstract = "Isodon xerophilus has been used as a herbal cold tea for the prevention and treatment of sore throat and inflammation in southernwestern China. A phytochemical study on the ethyl acetate (EtOAc) soluble fraction of I. xerophilus leaves led to the isolation of two new ent-kauranoids, xerophinoids A (1) and B (2), together with 14 known diterpenoids. The structures of xerophinoids A (1) and B (2) were illustrated using spectroscopic methods including 1D and 2D NMR analyses. To study their biological activities, the effects of xerophinoids A (1) and B (2) on nitrite production, tumor necrosis factor (TNF)-α and interleukin (IL)-1β were examined. In addition, xerophinoids A (1) and B (2) also exhibited potent cytotoxicity against several human tumor cell lines (IC50 < 11 μM), but they had no toxicity on human T-lymphocyte (C8166).",

keywords = "Anti-inflammation, Cytotoxicity, ent-kaurene diterpenoid, Herbal tea, Isodon xerophilus",

author = "Weng, {Zhi Ying} and Huang, {Sheng Xiong} and Li, {Ma Lin} and Zeng, {Yue Qin} and Han, {Quan Bin} and Rios, {Jose Luis} and Sun, {Han Dong}",

note = "This study was financially supported by the Natural Science Foundation of Yunnan Province (No. 2004C0008Z) and the National Natural Science Foundation of China (No. 20502026 to Q.-B.H.). Y.-Q.Z. is a recipient of an AECI (Spanish government) grant. ",

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T1 - Isolation of two bioactive ent-kauranoids from the leaves of Isodon xerophilus

AU - Weng, Zhi Ying

AU - Huang, Sheng Xiong

AU - Li, Ma Lin

AU - Zeng, Yue Qin

AU - Han, Quan Bin

AU - Rios, Jose Luis

AU - Sun, Han Dong

N1 - This study was financially supported by the Natural Science Foundation of Yunnan Province (No. 2004C0008Z) and the National Natural Science Foundation of China (No. 20502026 to Q.-B.H.). Y.-Q.Z. is a recipient of an AECI (Spanish government) grant.

PY - 2007/7/1

Y1 - 2007/7/1

N2 - Isodon xerophilus has been used as a herbal cold tea for the prevention and treatment of sore throat and inflammation in southernwestern China. A phytochemical study on the ethyl acetate (EtOAc) soluble fraction of I. xerophilus leaves led to the isolation of two new ent-kauranoids, xerophinoids A (1) and B (2), together with 14 known diterpenoids. The structures of xerophinoids A (1) and B (2) were illustrated using spectroscopic methods including 1D and 2D NMR analyses. To study their biological activities, the effects of xerophinoids A (1) and B (2) on nitrite production, tumor necrosis factor (TNF)-α and interleukin (IL)-1β were examined. In addition, xerophinoids A (1) and B (2) also exhibited potent cytotoxicity against several human tumor cell lines (IC50 < 11 μM), but they had no toxicity on human T-lymphocyte (C8166).

AB - Isodon xerophilus has been used as a herbal cold tea for the prevention and treatment of sore throat and inflammation in southernwestern China. A phytochemical study on the ethyl acetate (EtOAc) soluble fraction of I. xerophilus leaves led to the isolation of two new ent-kauranoids, xerophinoids A (1) and B (2), together with 14 known diterpenoids. The structures of xerophinoids A (1) and B (2) were illustrated using spectroscopic methods including 1D and 2D NMR analyses. To study their biological activities, the effects of xerophinoids A (1) and B (2) on nitrite production, tumor necrosis factor (TNF)-α and interleukin (IL)-1β were examined. In addition, xerophinoids A (1) and B (2) also exhibited potent cytotoxicity against several human tumor cell lines (IC50 < 11 μM), but they had no toxicity on human T-lymphocyte (C8166).

KW - Anti-inflammation

KW - Cytotoxicity

KW - ent-kaurene diterpenoid

KW - Herbal tea

KW - Isodon xerophilus

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Isolation of two bioactive ent-kauranoids from the leaves of Isodon xerophilus

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