Isolation and characterization of miscellaneous terpenoids of Schisandra chinensis

Sheng-Xiong Huang; Quan-Bin Han; Chun Lei; Jain-Xin Pu; Wei-Lie Xiao; Jun-Lin Yu; Liu-Meng Yang; Hong-Xi Xu; Yong-Tang Zheng; Han-Dong Sun

doi:10.1016/j.tet.2008.02.085

Isolation and characterization of miscellaneous terpenoids of Schisandra chinensis

Sheng-Xiong Huang, Quan-Bin Han, Chun Lei, Jain-Xin Pu, Wei-Lie Xiao, Jun-Lin Yu, Liu-Meng Yang, Hong-Xi Xu, Yong-Tang Zheng, Han-Dong Sun^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

66 Citations (Scopus)

Abstract

Two new bisnortriterpenoids with 18-norschiartane skeleton, wuweizidilactones G (1) and H (2), four new highly oxygenated nortriterpenoids based on a schisanartane skeleton, schindilactones D-G (3-6), a pre-schisanartane skeleton, pre-schisanartanin B (7), and a novel 3,4-seco-21,26-olide-artane triterpenoid wuweizilactone acid (8), along with 24 known terpenoids with different carbon frameworks, have been isolated from the acetone extract of the stems and leaves of Schisandra chinensis. The terpenoids produced by this plant have chemical diversity. The structures of new compounds 1-8 have been characterized by spectroscopic data interpretation. The cytotoxicity and anti-HIV-1 activity of all the Schisandra nortriterpenoids were evaluated.

Original language	English
Pages (from-to)	4260-4267
Number of pages	8
Journal	Tetrahedron
Volume	64
Issue number	19
DOIs	https://doi.org/10.1016/j.tet.2008.02.085
Publication status	Published - 5 May 2008

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title = "Isolation and characterization of miscellaneous terpenoids of Schisandra chinensis",

abstract = "Two new bisnortriterpenoids with 18-norschiartane skeleton, wuweizidilactones G (1) and H (2), four new highly oxygenated nortriterpenoids based on a schisanartane skeleton, schindilactones D-G (3-6), a pre-schisanartane skeleton, pre-schisanartanin B (7), and a novel 3,4-seco-21,26-olide-artane triterpenoid wuweizilactone acid (8), along with 24 known terpenoids with different carbon frameworks, have been isolated from the acetone extract of the stems and leaves of Schisandra chinensis. The terpenoids produced by this plant have chemical diversity. The structures of new compounds 1-8 have been characterized by spectroscopic data interpretation. The cytotoxicity and anti-HIV-1 activity of all the Schisandra nortriterpenoids were evaluated. ",

author = "Sheng-Xiong Huang and Quan-Bin Han and Chun Lei and Jain-Xin Pu and Wei-Lie Xiao and Jun-Lin Yu and Liu-Meng Yang and Hong-Xi Xu and Yong-Tang Zheng and Han-Dong Sun",

year = "2008",

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doi = "10.1016/j.tet.2008.02.085",

language = "English",

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T1 - Isolation and characterization of miscellaneous terpenoids of Schisandra chinensis

AU - Huang, Sheng-Xiong

AU - Han, Quan-Bin

AU - Lei, Chun

AU - Pu, Jain-Xin

AU - Xiao, Wei-Lie

AU - Yu, Jun-Lin

AU - Yang, Liu-Meng

AU - Xu, Hong-Xi

AU - Zheng, Yong-Tang

AU - Sun, Han-Dong

PY - 2008/5/5

Y1 - 2008/5/5

N2 - Two new bisnortriterpenoids with 18-norschiartane skeleton, wuweizidilactones G (1) and H (2), four new highly oxygenated nortriterpenoids based on a schisanartane skeleton, schindilactones D-G (3-6), a pre-schisanartane skeleton, pre-schisanartanin B (7), and a novel 3,4-seco-21,26-olide-artane triterpenoid wuweizilactone acid (8), along with 24 known terpenoids with different carbon frameworks, have been isolated from the acetone extract of the stems and leaves of Schisandra chinensis. The terpenoids produced by this plant have chemical diversity. The structures of new compounds 1-8 have been characterized by spectroscopic data interpretation. The cytotoxicity and anti-HIV-1 activity of all the Schisandra nortriterpenoids were evaluated.

AB - Two new bisnortriterpenoids with 18-norschiartane skeleton, wuweizidilactones G (1) and H (2), four new highly oxygenated nortriterpenoids based on a schisanartane skeleton, schindilactones D-G (3-6), a pre-schisanartane skeleton, pre-schisanartanin B (7), and a novel 3,4-seco-21,26-olide-artane triterpenoid wuweizilactone acid (8), along with 24 known terpenoids with different carbon frameworks, have been isolated from the acetone extract of the stems and leaves of Schisandra chinensis. The terpenoids produced by this plant have chemical diversity. The structures of new compounds 1-8 have been characterized by spectroscopic data interpretation. The cytotoxicity and anti-HIV-1 activity of all the Schisandra nortriterpenoids were evaluated.

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U2 - 10.1016/j.tet.2008.02.085

DO - 10.1016/j.tet.2008.02.085

M3 - Journal article

SN - 0040-4020

VL - 64

SP - 4260

EP - 4267

JO - Tetrahedron

JF - Tetrahedron

IS - 19

ER -

Isolation and characterization of miscellaneous terpenoids of Schisandra chinensis

Abstract

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