Isolation and characterization of cancer chemopreventive compounds from Barringtonia maunwongyathiae

Aranya Jutiviboonsuk, Hongjie ZHANG*, Tamara P. Kondratyuk, Angkana Herunsalee, Wongsatit Chaukul, John M. Pezzuto, Harry H.S. Fong, Nuntavan Bunyapraphatsara

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

18 Citations (Scopus)


A new plant species, Barringtonia maunwongyathiae W. Chuakul (Lecythidaceae), was recently discovered in Khuan Thon Forest, Ao Luek District, Krabi Province, Thailand. Chemical investigation of the leaves of this plant led to the isolation of 10 triterpenes, 3 steroids, and a vitamin E derivative. The structures of these compounds were identified as taraxerol (1), 3-(E)-coumaroyltaraxerol (2), 3-(Z)-coumaroyltaraxerol (3), 3-(E)-coumaroyl β-amyrin (4), 3-(Z)-coumaroyl β-amyrin (5), 3-(E)-coumaroyl α-amyrin (6), 3-(Z)-coumaroyl α-amyrin (7), 3-(E)-coumaroyllupeol (8), 3-(Z)-coumaroyllupeol (9), 3,19,24-trihydroxyurs-12-ene-28-oic acid (10), stigma-4,22-dien-3-one (11), β-stigmasterol (12), 3-O-β-D- glucopyranosyl-stigmasta-5,22-diene (13), and α-tocopherylquinone (14). All compounds were evaluated for their cancer chemopreventive potential based on inhibition of TPA-induced ornithine decarboxylase expression, COX-1 and COX-2 activities, and phorbol ester-induced NF-κB luciferase expression, as well as activation of antioxidant response element-mediated luciferase expression. Compounds 1, 2, and 14 demonstrated greatest promise, while 12 and 13 showed moderate activity.

Original languageEnglish
Pages (from-to)185-194
Number of pages10
JournalPharmaceutical Biology
Issue number3
Publication statusPublished - Mar 2007

Scopus Subject Areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

User-Defined Keywords

  • Antioxidant responsive element (ARE)
  • ARE luciferase reporter system
  • Barringtonia maunwongyathiae
  • Cancer chemoprevention
  • Coumaroyl triterpenes
  • COX-1
  • COX-2
  • Lecythidaceae
  • NF-κB luciferase reporter system
  • Ornithine decarboxylase (ODC)g48


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