Isobavachalcone attenuates Sephadex-induced lung injury via activation of A20 and NRF2/HO-1 in rats

Dehong Gao; Feng Liu; Zhipeng Li; Yifu  Guan

doi:10.1016/j.ejphar.2019.01.034

Isobavachalcone attenuates Sephadex-induced lung injury via activation of A20 and NRF2/HO-1 in rats

Dehong Gao, Feng Liu, Zhipeng Li^*, Yifu Guan^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

21 Citations (Scopus)

Abstract

The aim of this study is to investigate the protective effect and underlying molecular mechanisms of isobavachalcone on Sephadex-induced lung injury in rats. The result showed isobavachalcone inhibited massive granulomas, decreased inflammatory cells infiltration and oxidative stress markers level, but it can increase antioxidant enzymes level. The ELISA assay exhibited isobavachalcone decreased TNF-α production in BALF and lung tissue. Western blotting analysis showed isobavachalcone can inhibit NF-κB pathway that may be mediated by upregulation of A20. Furthermore, we also found isobavachalcone can activate NRF2/HO-1 pathway and inhibit adhesion molecule expression. Taken together, the present results suggested that isobavachalcone can attenuate Sephadex-induced lung injury that may be related to inhibition of NF-κB mediated by upregulation of A20 and activation of NRF2/HO-1 signaling pathway.

Original language	English
Pages (from-to)	49-54
Number of pages	6
Journal	European Journal of Pharmacology
Volume	848
DOIs	https://doi.org/10.1016/j.ejphar.2019.01.034
Publication status	Published - 5 Apr 2019

Scopus Subject Areas

Pharmacology

User-Defined Keywords

A20
Isobavachalcone
Lung injury
NF-κB
NRF2/HO-1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ejphar.2019.01.034

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title = "Isobavachalcone attenuates Sephadex-induced lung injury via activation of A20 and NRF2/HO-1 in rats",

abstract = "The aim of this study is to investigate the protective effect and underlying molecular mechanisms of isobavachalcone on Sephadex-induced lung injury in rats. The result showed isobavachalcone inhibited massive granulomas, decreased inflammatory cells infiltration and oxidative stress markers level, but it can increase antioxidant enzymes level. The ELISA assay exhibited isobavachalcone decreased TNF-α production in BALF and lung tissue. Western blotting analysis showed isobavachalcone can inhibit NF-κB pathway that may be mediated by upregulation of A20. Furthermore, we also found isobavachalcone can activate NRF2/HO-1 pathway and inhibit adhesion molecule expression. Taken together, the present results suggested that isobavachalcone can attenuate Sephadex-induced lung injury that may be related to inhibition of NF-κB mediated by upregulation of A20 and activation of NRF2/HO-1 signaling pathway.",

keywords = "A20, Isobavachalcone, Lung injury, NF-κB, NRF2/HO-1",

author = "Dehong Gao and Feng Liu and Zhipeng Li and Yifu Guan",

year = "2019",

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doi = "10.1016/j.ejphar.2019.01.034",

language = "English",

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journal = "European Journal of Pharmacology",

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TY - JOUR

T1 - Isobavachalcone attenuates Sephadex-induced lung injury via activation of A20 and NRF2/HO-1 in rats

AU - Gao, Dehong

AU - Liu, Feng

AU - Li, Zhipeng

AU - Guan, Yifu

PY - 2019/4/5

Y1 - 2019/4/5

N2 - The aim of this study is to investigate the protective effect and underlying molecular mechanisms of isobavachalcone on Sephadex-induced lung injury in rats. The result showed isobavachalcone inhibited massive granulomas, decreased inflammatory cells infiltration and oxidative stress markers level, but it can increase antioxidant enzymes level. The ELISA assay exhibited isobavachalcone decreased TNF-α production in BALF and lung tissue. Western blotting analysis showed isobavachalcone can inhibit NF-κB pathway that may be mediated by upregulation of A20. Furthermore, we also found isobavachalcone can activate NRF2/HO-1 pathway and inhibit adhesion molecule expression. Taken together, the present results suggested that isobavachalcone can attenuate Sephadex-induced lung injury that may be related to inhibition of NF-κB mediated by upregulation of A20 and activation of NRF2/HO-1 signaling pathway.

AB - The aim of this study is to investigate the protective effect and underlying molecular mechanisms of isobavachalcone on Sephadex-induced lung injury in rats. The result showed isobavachalcone inhibited massive granulomas, decreased inflammatory cells infiltration and oxidative stress markers level, but it can increase antioxidant enzymes level. The ELISA assay exhibited isobavachalcone decreased TNF-α production in BALF and lung tissue. Western blotting analysis showed isobavachalcone can inhibit NF-κB pathway that may be mediated by upregulation of A20. Furthermore, we also found isobavachalcone can activate NRF2/HO-1 pathway and inhibit adhesion molecule expression. Taken together, the present results suggested that isobavachalcone can attenuate Sephadex-induced lung injury that may be related to inhibition of NF-κB mediated by upregulation of A20 and activation of NRF2/HO-1 signaling pathway.

KW - A20

KW - Isobavachalcone

KW - Lung injury

KW - NF-κB

KW - NRF2/HO-1

UR - http://www.scopus.com/inward/record.url?scp=85060858148&partnerID=8YFLogxK

U2 - 10.1016/j.ejphar.2019.01.034

DO - 10.1016/j.ejphar.2019.01.034

M3 - Journal article

C2 - 30690005

AN - SCOPUS:85060858148

SN - 0014-2999

VL - 848

SP - 49

EP - 54

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

ER -

Isobavachalcone attenuates Sephadex-induced lung injury via activation of A20 and NRF2/HO-1 in rats

Abstract

Scopus Subject Areas

User-Defined Keywords

UN SDGs

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