Iron depletion decreases proliferation and induces apoptosis in a human colonic adenocarcinoma cell line, Caco2

Xuesong Sun, Ruiguang Ge, Zongwei CAI, Hongzhe Sun, Qing Yu He*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Iron is essential for maintaining cellular metabolism of most organisms. Iron chelators such as desferrioxamine have been used clinically in the treatment of iron overload diseases. In the present study, we used human colon adenocarcinoma cells as a proliferating cell model to validate that desferrioxamine inhibits cell proliferation and induces apoptosis. Proteomic analysis revealed that proteins involved in cell proliferation, signal transduction, metabolism and protein synthesis were significantly regulated by the availability of iron, rendering a close correlation between cell apoptosis and the disturbance of mitochondrial, signaling and metabolic pathways. These results provide new insights into the mechanisms of cell proliferation inhibition attributed to iron depletion.

Original languageEnglish
Pages (from-to)1074-1081
Number of pages8
JournalJournal of Inorganic Biochemistry
Volume103
Issue number7
DOIs
Publication statusPublished - Jul 2009

Scopus Subject Areas

  • Biochemistry
  • Inorganic Chemistry

User-Defined Keywords

  • Anti-proliferation
  • Apoptosis
  • Caco2 cell
  • Desferrioxamine
  • Mitochondria

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