Iridium(III) complexes with 1,10-phenanthroline-based N^N ligands as highly selective luminescent G-quadruplex probes and application for switch-on ribonuclease H detection

Lihua Lu*, Wanhe Wang, Chao Yang, Tian Shu Kang, Chung Hang Leung, Edmond Dik Lung MA

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

A systematic study was performed to investigate the relationship between molecular structure and G-quadruplex sensing ability for a series of structurally related cyclometallated iridium(iii) complexes. The novel complex 7 was used to construct a label-free luminescent switch-on G-quadruplex-based assay for RNase H activity in buffered solution. The constructed detection platform was simple, low-cost and highly sensitive for RNase H, and functioned effectively in the presence of cellular debris.

Original languageEnglish
Pages (from-to)6791-6796
Number of pages6
JournalJournal of Materials Chemistry B
Volume4
Issue number42
DOIs
Publication statusPublished - 2016

Scopus Subject Areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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