Iridium(III) Complexes Targeting Apoptotic Cell Death in Cancer Cells

Edmond Dik Lung Ma; Chun Wu; Ke Jia Wu; Chung Hang Leung

doi:10.3390/molecules24152739

Iridium(III) Complexes Targeting Apoptotic Cell Death in Cancer Cells

Edmond Dik Lung Ma
, Chun Wu
, Ke Jia Wu
, Chung Hang Leung

Department of Chemistry

Research output: Contribution to journal › Review article › peer-review

76 Citations (Scopus)

Abstract

Targeting apoptosis is a principal strategy in the design of anticancer drugs. In recent years, non-platinum-based scaffolds have been exploited as viable candidates for the exploitation of anticancer agents with potentially lower toxicity than the widely used cisplatin analogues. This review highlights the latest advances in developing iridium(III) complexes as anticancer agents that act particularly via targeting apoptotic cell death in cancer cells.

Original language	English
Journal	Molecules
Volume	24
Issue number	15
DOIs	https://doi.org/10.3390/molecules24152739
Publication status	Published - 28 Jul 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

User-Defined Keywords

apoptosis
cancer
iridium(III) complex
mitochondria

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10.3390/molecules24152739

Cite this

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title = "Iridium(III) Complexes Targeting Apoptotic Cell Death in Cancer Cells",

abstract = "Targeting apoptosis is a principal strategy in the design of anticancer drugs. In recent years, non-platinum-based scaffolds have been exploited as viable candidates for the exploitation of anticancer agents with potentially lower toxicity than the widely used cisplatin analogues. This review highlights the latest advances in developing iridium(III) complexes as anticancer agents that act particularly via targeting apoptotic cell death in cancer cells.",

keywords = "apoptosis, cancer, iridium(III) complex, mitochondria",

author = "Ma, \{Edmond Dik Lung\} and Chun Wu and Wu, \{Ke Jia\} and Leung, \{Chung Hang\}",

note = "Funding information: This research was funded by Hong Kong Baptist University (FRG2/17-18/003), the Health and Medical Research Fund (HMRF/14150561), the National Natural Science Foundation of China (21575121, 21775131 and 21762018), the Hong Kong Baptist University Century Club Sponsorship Scheme 2018, the Interdisciplinary Research Matching Scheme (RC-IRMS/16-17/03), the Interdisciplinary Research Clusters Matching Scheme (RC-IRCs/ 17-18/03), the Collaborative Research Fund (C5026-16G), the SKLEBA and HKBU Strategic Development Fund (SKLP\_1718\_P04), the Funded by The Science and Technology Development Fund, Macau SAR (File no. 0072/2018/A2), and the University of Macau (MYRG2016-00151-ICMS-QRCM and MYRG2018-00187-ICMS). ",

year = "2019",

month = jul,

day = "28",

doi = "10.3390/molecules24152739",

language = "English",

volume = "24",

journal = "Molecules",

issn = "1420-3049",

publisher = "MDPI",

number = "15",

}

TY - JOUR

T1 - Iridium(III) Complexes Targeting Apoptotic Cell Death in Cancer Cells

AU - Ma, Edmond Dik Lung

AU - Wu, Chun

AU - Wu, Ke Jia

AU - Leung, Chung Hang

N1 - Funding information: This research was funded by Hong Kong Baptist University (FRG2/17-18/003), the Health and Medical Research Fund (HMRF/14150561), the National Natural Science Foundation of China (21575121, 21775131 and 21762018), the Hong Kong Baptist University Century Club Sponsorship Scheme 2018, the Interdisciplinary Research Matching Scheme (RC-IRMS/16-17/03), the Interdisciplinary Research Clusters Matching Scheme (RC-IRCs/ 17-18/03), the Collaborative Research Fund (C5026-16G), the SKLEBA and HKBU Strategic Development Fund (SKLP_1718_P04), the Funded by The Science and Technology Development Fund, Macau SAR (File no. 0072/2018/A2), and the University of Macau (MYRG2016-00151-ICMS-QRCM and MYRG2018-00187-ICMS).

PY - 2019/7/28

Y1 - 2019/7/28

N2 - Targeting apoptosis is a principal strategy in the design of anticancer drugs. In recent years, non-platinum-based scaffolds have been exploited as viable candidates for the exploitation of anticancer agents with potentially lower toxicity than the widely used cisplatin analogues. This review highlights the latest advances in developing iridium(III) complexes as anticancer agents that act particularly via targeting apoptotic cell death in cancer cells.

AB - Targeting apoptosis is a principal strategy in the design of anticancer drugs. In recent years, non-platinum-based scaffolds have been exploited as viable candidates for the exploitation of anticancer agents with potentially lower toxicity than the widely used cisplatin analogues. This review highlights the latest advances in developing iridium(III) complexes as anticancer agents that act particularly via targeting apoptotic cell death in cancer cells.

KW - apoptosis

KW - cancer

KW - iridium(III) complex

KW - mitochondria

UR - https://www.scopus.com/pages/publications/85070757224

U2 - 10.3390/molecules24152739

DO - 10.3390/molecules24152739

M3 - Review article

C2 - 31357712

AN - SCOPUS:85070757224

SN - 1420-3049

VL - 24

JO - Molecules

JF - Molecules

IS - 15

ER -

Iridium(III) Complexes Targeting Apoptotic Cell Death in Cancer Cells

Abstract

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