Iridium(III) Complexes Targeting Apoptotic Cell Death in Cancer Cells

Edmond Dik Lung MA, Chun Wu, Ke Jia Wu, Chung Hang Leung

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)

Abstract

Targeting apoptosis is a principal strategy in the design of anticancer drugs. In recent years, non-platinum-based scaffolds have been exploited as viable candidates for the exploitation of anticancer agents with potentially lower toxicity than the widely used cisplatin analogues. This review highlights the latest advances in developing iridium(III) complexes as anticancer agents that act particularly via targeting apoptotic cell death in cancer cells.

Original languageEnglish
JournalMolecules
Volume24
Issue number15
DOIs
Publication statusPublished - 28 Jul 2019

Scopus Subject Areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

User-Defined Keywords

  • apoptosis
  • cancer
  • iridium(III) complex
  • mitochondria

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