Iridium(III) Complexes Targeting Apoptotic Cell Death in Cancer Cells

Edmond Dik Lung MA; Chun Wu; Ke Jia Wu; Chung Hang Leung

doi:10.3390/molecules24152739

Iridium(III) Complexes Targeting Apoptotic Cell Death in Cancer Cells

Edmond Dik Lung MA, Chun Wu, Ke Jia Wu, Chung Hang Leung

Department of Chemistry

Research output: Contribution to journal › Review article › peer-review

32 Citations (Scopus)

Abstract

Targeting apoptosis is a principal strategy in the design of anticancer drugs. In recent years, non-platinum-based scaffolds have been exploited as viable candidates for the exploitation of anticancer agents with potentially lower toxicity than the widely used cisplatin analogues. This review highlights the latest advances in developing iridium(III) complexes as anticancer agents that act particularly via targeting apoptotic cell death in cancer cells.

Original language	English
Journal	Molecules
Volume	24
Issue number	15
DOIs	https://doi.org/10.3390/molecules24152739
Publication status	Published - 28 Jul 2019

Scopus Subject Areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

User-Defined Keywords

apoptosis
cancer
iridium(III) complex
mitochondria

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/molecules24152739

Cite this

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title = "Iridium(III) Complexes Targeting Apoptotic Cell Death in Cancer Cells",

abstract = "Targeting apoptosis is a principal strategy in the design of anticancer drugs. In recent years, non-platinum-based scaffolds have been exploited as viable candidates for the exploitation of anticancer agents with potentially lower toxicity than the widely used cisplatin analogues. This review highlights the latest advances in developing iridium(III) complexes as anticancer agents that act particularly via targeting apoptotic cell death in cancer cells.",

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author = "MA, {Edmond Dik Lung} and Chun Wu and Wu, {Ke Jia} and Leung, {Chung Hang}",

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AU - MA, Edmond Dik Lung

AU - Wu, Chun

AU - Wu, Ke Jia

AU - Leung, Chung Hang

N1 - Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine

PY - 2019/7/28

Y1 - 2019/7/28

N2 - Targeting apoptosis is a principal strategy in the design of anticancer drugs. In recent years, non-platinum-based scaffolds have been exploited as viable candidates for the exploitation of anticancer agents with potentially lower toxicity than the widely used cisplatin analogues. This review highlights the latest advances in developing iridium(III) complexes as anticancer agents that act particularly via targeting apoptotic cell death in cancer cells.

AB - Targeting apoptosis is a principal strategy in the design of anticancer drugs. In recent years, non-platinum-based scaffolds have been exploited as viable candidates for the exploitation of anticancer agents with potentially lower toxicity than the widely used cisplatin analogues. This review highlights the latest advances in developing iridium(III) complexes as anticancer agents that act particularly via targeting apoptotic cell death in cancer cells.

KW - apoptosis

KW - cancer

KW - iridium(III) complex

KW - mitochondria

UR - http://www.scopus.com/inward/record.url?scp=85070757224&partnerID=8YFLogxK

U2 - 10.3390/molecules24152739

DO - 10.3390/molecules24152739

M3 - Review article

C2 - 31357712

AN - SCOPUS:85070757224

SN - 1420-3049

VL - 24

JO - Molecules

JF - Molecules

IS - 15

ER -

Iridium(III) Complexes Targeting Apoptotic Cell Death in Cancer Cells

Abstract

Scopus Subject Areas

User-Defined Keywords

UN SDGs

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