TY - JOUR
T1 - Iridium(iii) complexes decorated with silicane-modified rhodamine
T2 - near-infrared light-initiated photosensitizers for efficient deep-tissue penetration photodynamic therapy
AU - Liu, Jiqiang
AU - Yang, Xing
AU - Wu, Siye
AU - Gong, Ping
AU - Pan, Fan
AU - Zhang, Pengfei
AU - Lee, Chi Sing
AU - Liu, Chuangjun
AU - Wong, Keith Man Chung
N1 - The presented research was financially supported by the National Natural Science Foundation of China (grant no. 81671758 and 31571013), the Guangdong Natural Science Foundation of Research Team (2016A030312006), and the Shenzhen Science and Technology Program (grant no. JCYJ20160429191503002, JCYJ20170818162522440 and JCYJ20170818154843625). K. M. C. W. acknowledges the National Natural Science Foundation of China (grant no. 21771099) and the Science, Technology and Innovation Commission of Shenzhen Municipality (grant no. JCYJ20170817110721105 and JCYJ20190809165411528). P. G. acknowledges China Postdoctoral Science Foundation (2019M660219), Special Research Assistant Project of the Chinese Academy of Sciences (Y959101001) and Guangdong Basic and Applied Basic Research Fund Project (2019A1515110222). The authors acknowledge the SUSTech Core Research Facilities for technical support.
Publisher Copyright:
© 2024 The Royal Society of Chemistry.
PY - 2024/3/15
Y1 - 2024/3/15
N2 - Meeting the demand for efficient photosensitizers in photodynamic therapy (PDT), a series of iridium(III) complexes decorated with silicane-modified rhodamine (Si-rhodamine) was meticulously designed and synthesized. These complexes demonstrate exceptional PDT potential owing to their strong absorption in the near-infrared (NIR) spectrum, particularly responsive to 808 nm laser stimulation. This feature is pivotal, enabling deep-penetration laser excitation and overcoming depth-related challenges in clinical PDT applications. The molecular structures of these complexes allow for reliable tuning of singlet oxygen generation with NIR excitation, through modification of the cyclometalating ligand. Notably, one of the complexes (4) exhibits a remarkable ROS quantum yield of 0.69. In vivo results underscore the efficacy of 4, showcasing significant tumor regression at depths of up to 8.4 mm. This study introduces a promising paradigm for designing photosensitizers capable of harnessing NIR light effectively for deep PDT applications.
AB - Meeting the demand for efficient photosensitizers in photodynamic therapy (PDT), a series of iridium(III) complexes decorated with silicane-modified rhodamine (Si-rhodamine) was meticulously designed and synthesized. These complexes demonstrate exceptional PDT potential owing to their strong absorption in the near-infrared (NIR) spectrum, particularly responsive to 808 nm laser stimulation. This feature is pivotal, enabling deep-penetration laser excitation and overcoming depth-related challenges in clinical PDT applications. The molecular structures of these complexes allow for reliable tuning of singlet oxygen generation with NIR excitation, through modification of the cyclometalating ligand. Notably, one of the complexes (4) exhibits a remarkable ROS quantum yield of 0.69. In vivo results underscore the efficacy of 4, showcasing significant tumor regression at depths of up to 8.4 mm. This study introduces a promising paradigm for designing photosensitizers capable of harnessing NIR light effectively for deep PDT applications.
UR - http://www.scopus.com/inward/record.url?scp=85190836037&partnerID=8YFLogxK
U2 - 10.1039/d4tb00075g
DO - 10.1039/d4tb00075g
M3 - Journal article
C2 - 38529668
AN - SCOPUS:85190836037
SN - 2050-750X
VL - 12
SP - 3710
EP - 3718
JO - Journal of Materials Chemistry B
JF - Journal of Materials Chemistry B
IS - 15
ER -
