Iridium(III) Complexes containing 1,10-Phenanthroline and Derivatives – Synthetic, Stereochemical and Structural Studies, and their Antimicrobial Activity.

Mallesh Pandrala, Fangfei LI, Lynne Wallace*, Peter J. Steel, Barry Moore II II, Jochen Autschbach, J. Grant Collins*, F. Richard Keene*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

19 Citations (Scopus)

Abstract

A convenient synthetic strategy is reported for the series of complexes [Ir(pp)3]3+ (where pp = phen, Me2phen and Me4phen) through the intermediacy of the appropriate [Ir(pp)2(CF3SO3)2]+ species. In the case of [Ir(phen)3]3+, the cation was resolved into its enantiomeric forms, for which the absolute configurations were determined by X-ray diffraction. The availability for the first time of the CD spectra allowed comparison with computed CD spectra. Measurement of the antimicrobial activity of the [Ir(pp)3]3+ species {and the [Ir(pp)2X2]+ (X = Cl, CF3SO3) precursors involved in their synthesis}, as well as cell uptake studies with the four bacterial strains S. aureus, methicillin-resistant S. aureus (MRSA), E. coli, and P. aeruginosa, indicated that they showed little activity compared with their Ru(II) analogues. The results suggest that it is unfavourable for an individual metal centre with a 3+ charge to pass across the bacterial cell membrane.
Original languageEnglish
Pages (from-to)1065-1073
Number of pages9
JournalAustralian Journal of Chemistry
Volume66
Issue number9
DOIs
Publication statusPublished - Jul 2013
Externally publishedYes

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