Iridium-catalyzed asymmetric hydroalkynylation reactions of oxabenzonorbornadienes

Jun Hu; Qingjing Yang; Jianbin Xu; Chao Huang; Baomin Fan; Jun WANG; Chengyuan Lin; Zhaoxiang BIAN; Albert S C Chan

doi:10.1039/c2ob26775f

Iridium-catalyzed asymmetric hydroalkynylation reactions of oxabenzonorbornadienes

Jun Hu
, Qingjing Yang
, Jianbin Xu
, Chao Huang
, Baomin Fan^*
, Jun WANG
, Chengyuan Lin
, Zhaoxiang BIAN
, Albert S C Chan

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

49 Citations (Scopus)

Abstract

Oxabenzonorbornadienes were found to be suitable substrates for asymmetric hydroalkynylation reactions. Catalyzed by the complex of [Ir(COD)Cl]₂ and (R)-SYNPHOS, oxabenzonorbornadienes and terminal alkynes could react smoothly to give the alkynylated products in moderate to good yields (up to 93% yield) and enantioselectivities (up to 85% ee).

Original language	English
Pages (from-to)	814-820
Number of pages	7
Journal	Organic and Biomolecular Chemistry
Volume	11
Issue number	5
DOIs	https://doi.org/10.1039/c2ob26775f
Publication status	Published - 7 Feb 2013

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title = "Iridium-catalyzed asymmetric hydroalkynylation reactions of oxabenzonorbornadienes",

abstract = "Oxabenzonorbornadienes were found to be suitable substrates for asymmetric hydroalkynylation reactions. Catalyzed by the complex of [Ir(COD)Cl]2 and (R)-SYNPHOS, oxabenzonorbornadienes and terminal alkynes could react smoothly to give the alkynylated products in moderate to good yields (up to 93\% yield) and enantioselectivities (up to 85\% ee).",

author = "Jun Hu and Qingjing Yang and Jianbin Xu and Chao Huang and Baomin Fan and Jun WANG and Chengyuan Lin and Zhaoxiang BIAN and Chan, \{Albert S C\}",

year = "2013",

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doi = "10.1039/c2ob26775f",

language = "English",

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TY - JOUR

T1 - Iridium-catalyzed asymmetric hydroalkynylation reactions of oxabenzonorbornadienes

AU - Hu, Jun

AU - Yang, Qingjing

AU - Xu, Jianbin

AU - Huang, Chao

AU - Fan, Baomin

AU - WANG, Jun

AU - Lin, Chengyuan

AU - BIAN, Zhaoxiang

AU - Chan, Albert S C

PY - 2013/2/7

Y1 - 2013/2/7

N2 - Oxabenzonorbornadienes were found to be suitable substrates for asymmetric hydroalkynylation reactions. Catalyzed by the complex of [Ir(COD)Cl]2 and (R)-SYNPHOS, oxabenzonorbornadienes and terminal alkynes could react smoothly to give the alkynylated products in moderate to good yields (up to 93% yield) and enantioselectivities (up to 85% ee).

AB - Oxabenzonorbornadienes were found to be suitable substrates for asymmetric hydroalkynylation reactions. Catalyzed by the complex of [Ir(COD)Cl]2 and (R)-SYNPHOS, oxabenzonorbornadienes and terminal alkynes could react smoothly to give the alkynylated products in moderate to good yields (up to 93% yield) and enantioselectivities (up to 85% ee).

UR - https://www.scopus.com/pages/publications/84872058335

U2 - 10.1039/c2ob26775f

DO - 10.1039/c2ob26775f

M3 - Journal article

AN - SCOPUS:84872058335

SN - 1477-0520

VL - 11

SP - 814

EP - 820

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 5

ER -

Iridium-catalyzed asymmetric hydroalkynylation reactions of oxabenzonorbornadienes

Abstract

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