Iridium-catalyzed asymmetric hydroalkynylation reactions of oxabenzonorbornadienes

Jun Hu, Qingjing Yang, Jianbin Xu, Chao Huang, Baomin Fan*, Jun WANG, Chengyuan Lin, Zhaoxiang BIAN, Albert S C Chan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

Oxabenzonorbornadienes were found to be suitable substrates for asymmetric hydroalkynylation reactions. Catalyzed by the complex of [Ir(COD)Cl]2 and (R)-SYNPHOS, oxabenzonorbornadienes and terminal alkynes could react smoothly to give the alkynylated products in moderate to good yields (up to 93% yield) and enantioselectivities (up to 85% ee).

Original languageEnglish
Pages (from-to)814-820
Number of pages7
JournalOrganic and Biomolecular Chemistry
Volume11
Issue number5
DOIs
Publication statusPublished - 7 Feb 2013

Scopus Subject Areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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