Iridium-based probe for luminescent nitric oxide monitoring in live cells

Chun Wu, Ke Jia Wu, Tian Shu Kang, Hui Min David Wang, Chung Hang Leung, Jin Biao Liu*, Edmond Dik Lung MA

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

17 Citations (Scopus)


Nitric oxide (NO) is an intra- and extracellular messenger with important functions during human physiology process. A long-lived luminescent iridium(III) complex probe 1 has been designed and synthesized for the monitoring of NO controllably released from sodium nitroprusside (SNP). Probe 1 displayed a 15-fold switch-on luminescence in the presence of SNP at 580 nm. The probe exhibited a linear response towards SNP between 5 to 25 μM with detection limit at 0.18 μM. Importantly, the luminescent switch-on detection of NO in HeLa cells was demonstrated. Overall, complex 1 has the potential to be applied for NO tracing in complicated cellular environment.

Original languageEnglish
Article number12467
JournalScientific Reports
Issue number1
Publication statusPublished - 1 Dec 2018

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