Investigation of the preparation, characterization, and whitening activity of co-amorphous glabridin and oxymatrine

Peiyi Liang, Yi Hu, Zhuxian Wang, Yinglin Guo, Hongkai Chen, Cui Ping Jiang, Quanfu Zeng, Chunyan Shen, Yufan Wu, Li Liu, Yankui Yi, Hongxia Zhu*, Zhijun Yang*, Qiang Liu*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review


Glabridin (Gla) is a natural active ingredient extracted from licorice root with good whitening activity. However, its poor solubility limits its further application. Therefore, this study aimed to develop a novel co-amorphous Gla-OMT raw material using oxymatrine (OMT) as a co-former, aiming to improve its physicochemical properties and enhance its whitening activity. Firstly, the formation of co-amorphous Gla-OMT was confirmed by powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC). Subsequently, FT-IR, NMR, and molecular dynamics simulations were used to investigate the interaction between the co-amorphous Gla-OMT molecules, and solubility experiments and supersaturation dissolution experiments were used to investigate the solubilization of the co-amorphous Gla-OMT. In addition, the in vitro release mechanism of the co-amorphous Gla-OMT was investigated using a Franz diffusion cell and its biosafety and whitening activity were evaluated using cell experiments. In conclusion, the successful preparation of co-amorphous Gla-OMT and the evaluation of its whitening activity in this study have significant implications for guiding the development and application of whitening products in the future.

Original languageEnglish
Pages (from-to)6252-6265
Number of pages14
Issue number45
Early online date26 Sept 2023
Publication statusPublished - 7 Dec 2023

Scopus Subject Areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics


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