Investigation of retinoic acid induced phenotype of neuroblastoma cells

Yuqiang Fang; King W.C. Lai; Cathy N.P. Lui; Carmen K.M. Fung; Hung Wing LI; Kin Lam YUNG; Ning Xi

doi:10.1109/NANO.2014.6968089

Investigation of retinoic acid induced phenotype of neuroblastoma cells

Yuqiang Fang
, King W.C. Lai
, Cathy N.P. Lui
, Carmen K.M. Fung
, Hung Wing LI
, Kin Lam YUNG
, Ning Xi

Research output: Chapter in book/report/conference proceeding › Conference proceeding › peer-review

1 Citation (Scopus)

Abstract

Retinoic acid and its synthetic derivatives are considered as potential agents in cancer therapy because of its pharmacological effect to promote differentiation and to inhibit proliferation of cancer cells. However, clinical trials are greatly hindered by the side effect of retinoic acid with pharmacological dose and limited knowledge of retinoic acid functionalizing exerted on entire cells. Here, we applied atomic force microscopy as a less invasive approach to monitor the retinoic acid induced effect on entire live neuroblastoma cells. Our studies demonstrated that the live SH-SY5Y cells were stiffened and demonstrated the morphology of orientated growth. The Young's modulus and surface roughness of cells were increased under retinoic acid stimulus, which could serve as novel indicators for possibly development of anti-cancer drug screening.

Original language	English
Title of host publication	Proceedings of the 14th IEEE International Conference on Nanotechnology
Publisher	IEEE
Pages	4-7
Number of pages	4
ISBN (Electronic)	9781479956227
DOIs	https://doi.org/10.1109/NANO.2014.6968089
Publication status	Published - 18 Aug 2014
Event	2014 14th IEEE International Conference on Nanotechnology, IEEE-NANO 2014 - Toronto, Canada Duration: 18 Aug 2014 → 21 Aug 2014

Publication series

Name	IEEE International Conference on Nanotechnology
ISSN (Print)	1944-9399

Conference

Conference	2014 14th IEEE International Conference on Nanotechnology, IEEE-NANO 2014
Country/Territory	Canada
City	Toronto
Period	18/08/14 → 21/08/14

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1109/NANO.2014.6968089

Cite this

@inproceedings{983c17c5ab0d477b8d5221275f4d79a5,

title = "Investigation of retinoic acid induced phenotype of neuroblastoma cells",

abstract = "Retinoic acid and its synthetic derivatives are considered as potential agents in cancer therapy because of its pharmacological effect to promote differentiation and to inhibit proliferation of cancer cells. However, clinical trials are greatly hindered by the side effect of retinoic acid with pharmacological dose and limited knowledge of retinoic acid functionalizing exerted on entire cells. Here, we applied atomic force microscopy as a less invasive approach to monitor the retinoic acid induced effect on entire live neuroblastoma cells. Our studies demonstrated that the live SH-SY5Y cells were stiffened and demonstrated the morphology of orientated growth. The Young's modulus and surface roughness of cells were increased under retinoic acid stimulus, which could serve as novel indicators for possibly development of anti-cancer drug screening.",

author = "Yuqiang Fang and Lai, \{King W.C.\} and Lui, \{Cathy N.P.\} and Fung, \{Carmen K.M.\} and LI, \{Hung Wing\} and YUNG, \{Kin Lam\} and Ning Xi",

note = "Publisher Copyright: {\textcopyright} 2014 IEEE.; 2014 14th IEEE International Conference on Nanotechnology, IEEE-NANO 2014 ; Conference date: 18-08-2014 Through 21-08-2014",

year = "2014",

month = aug,

day = "18",

doi = "10.1109/NANO.2014.6968089",

language = "English",

series = "IEEE International Conference on Nanotechnology",

publisher = "IEEE",

pages = "4--7",

booktitle = "Proceedings of the 14th IEEE International Conference on Nanotechnology",

address = "United States",

}

Fang, Y, Lai, KWC, Lui, CNP, Fung, CKM, LI, HW, YUNG, KL & Xi, N 2014, Investigation of retinoic acid induced phenotype of neuroblastoma cells. in Proceedings of the 14th IEEE International Conference on Nanotechnology. IEEE International Conference on Nanotechnology, IEEE, pp. 4-7, 2014 14th IEEE International Conference on Nanotechnology, IEEE-NANO 2014, Toronto, Canada, 18/08/14. https://doi.org/10.1109/NANO.2014.6968089

Investigation of retinoic acid induced phenotype of neuroblastoma cells. / Fang, Yuqiang; Lai, King W.C.; Lui, Cathy N.P. et al.
Proceedings of the 14th IEEE International Conference on Nanotechnology. IEEE, 2014. p. 4-7 (IEEE International Conference on Nanotechnology).

Research output: Chapter in book/report/conference proceeding › Conference proceeding › peer-review

TY - GEN

T1 - Investigation of retinoic acid induced phenotype of neuroblastoma cells

AU - Fang, Yuqiang

AU - Lai, King W.C.

AU - Lui, Cathy N.P.

AU - Fung, Carmen K.M.

AU - LI, Hung Wing

AU - YUNG, Kin Lam

AU - Xi, Ning

PY - 2014/8/18

Y1 - 2014/8/18

N2 - Retinoic acid and its synthetic derivatives are considered as potential agents in cancer therapy because of its pharmacological effect to promote differentiation and to inhibit proliferation of cancer cells. However, clinical trials are greatly hindered by the side effect of retinoic acid with pharmacological dose and limited knowledge of retinoic acid functionalizing exerted on entire cells. Here, we applied atomic force microscopy as a less invasive approach to monitor the retinoic acid induced effect on entire live neuroblastoma cells. Our studies demonstrated that the live SH-SY5Y cells were stiffened and demonstrated the morphology of orientated growth. The Young's modulus and surface roughness of cells were increased under retinoic acid stimulus, which could serve as novel indicators for possibly development of anti-cancer drug screening.

AB - Retinoic acid and its synthetic derivatives are considered as potential agents in cancer therapy because of its pharmacological effect to promote differentiation and to inhibit proliferation of cancer cells. However, clinical trials are greatly hindered by the side effect of retinoic acid with pharmacological dose and limited knowledge of retinoic acid functionalizing exerted on entire cells. Here, we applied atomic force microscopy as a less invasive approach to monitor the retinoic acid induced effect on entire live neuroblastoma cells. Our studies demonstrated that the live SH-SY5Y cells were stiffened and demonstrated the morphology of orientated growth. The Young's modulus and surface roughness of cells were increased under retinoic acid stimulus, which could serve as novel indicators for possibly development of anti-cancer drug screening.

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DO - 10.1109/NANO.2014.6968089

M3 - Conference proceeding

AN - SCOPUS:84919468112

T3 - IEEE International Conference on Nanotechnology

SP - 4

EP - 7

BT - Proceedings of the 14th IEEE International Conference on Nanotechnology

PB - IEEE

T2 - 2014 14th IEEE International Conference on Nanotechnology, IEEE-NANO 2014

Y2 - 18 August 2014 through 21 August 2014

ER -

Investigation of retinoic acid induced phenotype of neuroblastoma cells

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