Investigation of retinoic acid induced phenotype of neuroblastoma cells

Yuqiang Fang, King W.C. Lai, Cathy N.P. Lui, Carmen K.M. Fung, Hung Wing LI, Kin Lam YUNG, Ning Xi

Research output: Chapter in book/report/conference proceedingConference contributionpeer-review

1 Citation (Scopus)

Abstract

Retinoic acid and its synthetic derivatives are considered as potential agents in cancer therapy because of its pharmacological effect to promote differentiation and to inhibit proliferation of cancer cells. However, clinical trials are greatly hindered by the side effect of retinoic acid with pharmacological dose and limited knowledge of retinoic acid functionalizing exerted on entire cells. Here, we applied atomic force microscopy as a less invasive approach to monitor the retinoic acid induced effect on entire live neuroblastoma cells. Our studies demonstrated that the live SH-SY5Y cells were stiffened and demonstrated the morphology of orientated growth. The Young's modulus and surface roughness of cells were increased under retinoic acid stimulus, which could serve as novel indicators for possibly development of anti-cancer drug screening.

Original languageEnglish
Title of host publication14th IEEE International Conference on Nanotechnology, IEEE-NANO 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages4-7
Number of pages4
ISBN (Electronic)9781479956227
DOIs
Publication statusPublished - 26 Nov 2014
Event2014 14th IEEE International Conference on Nanotechnology, IEEE-NANO 2014 - Toronto, Canada
Duration: 18 Aug 201421 Aug 2014

Publication series

Name14th IEEE International Conference on Nanotechnology, IEEE-NANO 2014

Conference

Conference2014 14th IEEE International Conference on Nanotechnology, IEEE-NANO 2014
Country/TerritoryCanada
CityToronto
Period18/08/1421/08/14

Scopus Subject Areas

  • Electrical and Electronic Engineering
  • Computer Science Applications
  • Modelling and Simulation
  • Instrumentation

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