Investigation of N-methyl-D-aspartate induced mechanical behavior of neuroblastoma cells using atomic force microscopy

Yuqiang Fang, King W.C. Lai, Catherine Y.Y. Iu, Cathy N.P. Lui, Carmen K.M. Fung, Hung Wing LI, Kin Lam YUNG, Ning Xi

Research output: Chapter in book/report/conference proceedingConference contributionpeer-review

Abstract

Physiological conditions of biological samples are regulated by many different parameters including mechanical and biochemical factors etc. Single-cell studies of these parameters are challenging by using conventional bioanalysis methods. However, with the recent advancement in nanotechnology, single-molecule and single-cell analysis is much more accessible. Understanding the changes of neuroblastoma cells in different mechanisms is critical for fundamental research in neurosciences. Here, we investigate the mechanical behavior of SH-SY5Y cells using atomic force microscopy. Topographic imaging of the cells and real-time quantitative analysis of their mechanical properties will be presented in the paper.

Original languageEnglish
Title of host publication2013 13th IEEE International Conference on Nanotechnology, IEEE-NANO 2013
Pages329-332
Number of pages4
DOIs
Publication statusPublished - 2013
Event2013 13th IEEE International Conference on Nanotechnology, IEEE-NANO 2013 - Beijing, China
Duration: 5 Aug 20138 Aug 2013

Publication series

NameProceedings of the IEEE Conference on Nanotechnology
ISSN (Print)1944-9399
ISSN (Electronic)1944-9380

Conference

Conference2013 13th IEEE International Conference on Nanotechnology, IEEE-NANO 2013
Country/TerritoryChina
CityBeijing
Period5/08/138/08/13

Scopus Subject Areas

  • Bioengineering
  • Electrical and Electronic Engineering
  • Materials Chemistry
  • Condensed Matter Physics

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