Inverse correlation between longevity and developmental rate among wild C. elegans strains

Yujin Lee, Wooseon Hwang, Juyoung Jung, Sangsoon Park, Josephine Jill T. Cabatbat, Pan Jun Kim, Seung Jae V. Lee*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

13 Citations (Scopus)

Abstract

Genetic studies using model organisms have shown that many long-lived mutants display impaired fitness, such as reduced fecundity and delayed development. However, in several wild animals, the association between longevity and fitness does not seem to be inevitable. Thus, the relationship between longevity and fitness in wild organisms remains inconclusive. Here, we determined the correlation between lifespan and fitness, developmental rate and brood size, by using 16 wild-derived C. elegans strains originated from various geographic areas. We found a negative correlation between lifespan and developmental rate. In contrast, we did not find such negative correlation between longevity and developmental rate among the individuals of C. elegans strains. These data imply that polymorphic genetic variants among wild isolates determine resource allocation to longevity and developmental rate.

Original languageEnglish
Pages (from-to)986-999
Number of pages14
JournalAging
Volume8
Issue number5
DOIs
Publication statusPublished - May 2016
Externally publishedYes

Scopus Subject Areas

  • Ageing
  • Cell Biology

User-Defined Keywords

  • Aging
  • C. elegans
  • Development
  • Fitness
  • lifespan
  • Reproduction

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