Intracellular signaling pathways of inflammation modulated by dietary flavonoids: The most recent evidence

Lei Chen, Hui Teng, Zhen Jia, Maurizio Battino, Anca Miron, Zhiling Yu*, Hui Cao, Jianbo Xiao*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

133 Citations (Scopus)


Dietary flavonoids, which occur in many plant foods, are considered as the most active constituents among the plant-derived ones in vitro and in vivo. To date, many studies have addressed the anti-inflammatory activity of flavonoids. However, their considerable structural diversity and in vivo bioavailability make them able to modulate different signaling pathways. The present review attempted to summarize and highlight a broad range of inflammation-associated signaling pathways modulated by flavonoids. Finally, based on the current scientist's literature, structure-activity relationships were concluded. Dietary flavonoids have the ability to attenuate inflammation by targeting different intracellular signaling pathways triggered by NF-κB, AP-1, PPAR, Nrf2, and MAPKs. Identification of the main structural features required for the modulation of these inflammation-related pathways (hydroxylation pattern, C2=C3 double bond) have an important role to play in the development of new anti-inflammatory drugs.

Original languageEnglish
Pages (from-to)2908-2924
Number of pages17
JournalCritical Reviews in Food Science and Nutrition
Issue number17
Early online date29 Sept 2017
Publication statusPublished - 22 Nov 2018

Scopus Subject Areas

  • Food Science
  • Industrial and Manufacturing Engineering

User-Defined Keywords

  • Flavonoids
  • inflammation
  • intracellular signaling pathways
  • structure-activity relationship


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