TY - JOUR
T1 - Interaction of ncRNA and Epigenetic Modifications in Gastric Cancer
T2 - Focus on Histone Modification
AU - Yang, Qingfan
AU - Chen, Yu
AU - Guo, Rui
AU - Dai, Yalan
AU - Tang, Liyao
AU - Zhao, Yueshui
AU - Wu, Xu
AU - Li, Mingxing
AU - Du, Fukuan
AU - Shen, Jing
AU - Yi, Tao
AU - Xiao, Zhangang
AU - Wen, Qinglian
N1 - Funding Information:
ZX is thankful to the National Natural Science Foundation of China (Grants 81503093, 81972643, and 81672444) for the financial supports.
Publisher Copyright:
Copyright © 2022 Yang, Chen, Guo, Dai, Tang, Zhao, Wu, Li, Du, Shen, Yi, Xiao and Wen.
PY - 2022/1/26
Y1 - 2022/1/26
N2 - Gastric cancer has developed as a very common gastrointestinal tumors, with recent effective advancements in the diagnosis and treatment of early gastric cancer. However, the prognosis for gastric cancer remains poor. As a result, there is in sore need of better understanding the mechanisms of gastric cancer development and progression to improve existing diagnostic and treatment options. In recent years, epigenetics has been recognized as an important contributor on tumor progression. Epigenetic changes in cancer include chromatin remodeling, DNA methylation and histone modifications. An increasing number of studies demonstrated that noncoding RNAs (ncRNAs) are associated with epigenetic changes in gastric cancer. Herein, we describe the molecular interactions of histone modifications and ncRNAs in epigenetics. We focus on ncRNA-mediated histone modifications of gene expression associated with tumorigenesis and progression in gastric cancer. This molecular mechanism will contribute to our deeper understanding of gastric carcinogenesis and progression, thus providing innovations in gastric cancer diagnosis and treatment strategies.
AB - Gastric cancer has developed as a very common gastrointestinal tumors, with recent effective advancements in the diagnosis and treatment of early gastric cancer. However, the prognosis for gastric cancer remains poor. As a result, there is in sore need of better understanding the mechanisms of gastric cancer development and progression to improve existing diagnostic and treatment options. In recent years, epigenetics has been recognized as an important contributor on tumor progression. Epigenetic changes in cancer include chromatin remodeling, DNA methylation and histone modifications. An increasing number of studies demonstrated that noncoding RNAs (ncRNAs) are associated with epigenetic changes in gastric cancer. Herein, we describe the molecular interactions of histone modifications and ncRNAs in epigenetics. We focus on ncRNA-mediated histone modifications of gene expression associated with tumorigenesis and progression in gastric cancer. This molecular mechanism will contribute to our deeper understanding of gastric carcinogenesis and progression, thus providing innovations in gastric cancer diagnosis and treatment strategies.
KW - epigenetic modifications
KW - gastric cancer
KW - histone modification
KW - mechanisms
KW - ncRNA
UR - http://www.scopus.com/inward/record.url?scp=85124567901&partnerID=8YFLogxK
U2 - 10.3389/fonc.2021.822745
DO - 10.3389/fonc.2021.822745
M3 - Review article
C2 - 35155211
AN - SCOPUS:85124567901
SN - 2234-943X
VL - 11
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 822745
ER -
