Interaction between oseltamivir and herbal medicines used for treating avian influenza

Mildred S. Yang*, F. C.P. Law, Ricky N S WONG, Nai Ki MAK, X. Y. Wei

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

11 Citations (Scopus)

Abstract

1. In vitro studies were used to investigate the effect of various herbal medicines on the activity of drug-metabolising enzymes, whereas a PBPK model was used to study the interaction between oseltamivir (Tamiflu) and herbal medicines.
2. The biochemical and molecular biological basis of drug-herb interactions were studied by determining the effect of herbal extracts on cellular redox states and gene expression profiles.
3. Herbal extracts may affect oseltamivir treatment in rats. The drug-herb interaction may be related either to the metabolism or uptake of the drug by different tissues. Further studies are necessary to determine whether such interactions also occur in humans.
Original languageEnglish
Pages (from-to)S34-S36
Number of pages3
JournalHong Kong Medical Journal
Volume18
Issue number6, Suppl 6
Publication statusPublished - Dec 2012

Scopus Subject Areas

  • Medicine(all)

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