Integrating in silico prediction methods, molecular docking, and molecular dynamics simulation to predict the impact of ALK missense mutations in structural perspective

Medicine & Life Sciences

• Anaplastic Lymphoma Kinase 100%
• Molecular Dynamics Simulation 83%
• Missense Mutation 77%
• Computer Simulation 70%
• Single Nucleotide Polymorphism 62%
• Precision Medicine 40%
• Mutation 31%
• Pharmaceutical Preparations 31%
• Genotype 26%
• Disease Susceptibility 20%
• High-Throughput Nucleotide Sequencing 17%
• Drug Development 17%
• Technology 12%
• Costs and Cost Analysis 11%
• Phenotype 11%
• Proteins 6%
• Therapeutics 3%

Chemical Compounds

• Mutation 63%
• Nucleotide 61%
• Molecular Dynamics 54%
• Simulation 47%
• Pipeline 43%
• Drug 39%
• Drug Target 21%
• Protein 7%
• Time 6%
• Application 5%