TY - JOUR
T1 - Insights into the unique roles of extracellular vesicles for gut health modulation
T2 - Mechanisms, challenges, and perspectives
AU - Wu, Qiming
AU - Kan, Juntao
AU - Fu, Caili
AU - Liu, Xin
AU - Cui, Zhengying
AU - Wang, Sixu
AU - Le, Yi
AU - Li, Zhanming
AU - Liu, Qin
AU - Zhang, Yuyu
AU - Du, Jun
N1 - Funding Information:
This work was supported by Science and Technology Project of Jiangsu Province, Grant No.: BZ2022056; National Natural Science Foundation of China, Grant No.: 32122069; the Cooperation project of Amway China Co., Limited and the National University of Singapore Suzhou Research Institute, Grant No's.: Am20220229RD, Am20230595RD; Innovation and Technology Fund, Hong Kong, Grant No.: ITS/148/14FP to Z-X.B; the Key Research and Development Project of Hainan Province, Grant No.: ZDYF2024XDNY204.
Publisher Copyright:
© 2024 The Authors. Published by Elsevier B.V.
PY - 2024/12
Y1 - 2024/12
N2 - Extracellular vesicles (EVs), which play significant regulatory roles in maintaining homeostasis and influencing immune responses, significantly impact gut microbiota composition and function, affecting overall gut health. Despite considerable progress, there are still knowledge gaps regarding the mechanisms by which EVs, including plant-derived EVs (PDEVs), animal-derived EVs (ADEVs), and microbiota-derived EVs (MDEVs), modulate gut health. This review delves into the roles and mechanisms of EVs from diverse sources in regulating gut health, focusing on their contributions to maintaining epithelial barrier integrity, facilitating tissue healing, eliciting immune responses, controlling pathogens, and shaping microbiota. We emphasize open challenges and future perspectives for harnessing EVs in the modulation of gut health to gain a deeper understanding of their roles and impact. Importantly, a comprehensive research framework is presented to steer future investigations into the roles and implications of EVs on gut health, facilitating a more profound comprehension of this emerging field.
AB - Extracellular vesicles (EVs), which play significant regulatory roles in maintaining homeostasis and influencing immune responses, significantly impact gut microbiota composition and function, affecting overall gut health. Despite considerable progress, there are still knowledge gaps regarding the mechanisms by which EVs, including plant-derived EVs (PDEVs), animal-derived EVs (ADEVs), and microbiota-derived EVs (MDEVs), modulate gut health. This review delves into the roles and mechanisms of EVs from diverse sources in regulating gut health, focusing on their contributions to maintaining epithelial barrier integrity, facilitating tissue healing, eliciting immune responses, controlling pathogens, and shaping microbiota. We emphasize open challenges and future perspectives for harnessing EVs in the modulation of gut health to gain a deeper understanding of their roles and impact. Importantly, a comprehensive research framework is presented to steer future investigations into the roles and implications of EVs on gut health, facilitating a more profound comprehension of this emerging field.
KW - Extracellular vesicles
KW - Gut barrier
KW - Gut health
KW - Immune responses
KW - Microbiota
UR - http://www.scopus.com/inward/record.url?scp=85207724104&partnerID=8YFLogxK
U2 - 10.1016/j.crmicr.2024.100301
DO - 10.1016/j.crmicr.2024.100301
M3 - Journal article
AN - SCOPUS:85207724104
SN - 2666-5174
VL - 7
JO - Current Research in Microbial Sciences
JF - Current Research in Microbial Sciences
M1 - 100301
ER -
