In(OTf)3-Catalyzed Cascade Cyclization for Construction of Oxatricyclic Compounds

Wenli Bao, Yezi Tao, Jiangqun Cheng, Junrong Huang, Jingming Cao, Mengxun Zhang, Weijian Ye, Bo Wang, Yang Li, Lizhi Zhu, Chi Sing Lee*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

6 Citations (Scopus)


A highly diastereoselective cascade cyclization reaction has been developed for establishing a series of oxatricyclic compounds using Chan's diene and simple keto alkynal substrates with only 1 mol % of In(OTf)3 as the catalyst in 82-92% yields. The potential utility of this synthetic strategy has been demonstrated in model studies for the construction the core structures of 1α,8α:4α,5α-diepoxy-4,5-dihydroosmitopsin and cortistatin A.

Original languageEnglish
Pages (from-to)7912-7915
Number of pages4
JournalOrganic Letters
Issue number24
Publication statusPublished - 21 Dec 2018

Scopus Subject Areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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