@article{c1b17bc5d7f94d478760dc458e6d08f3,
title = "Inhibition of TLR1/2 dimerization by enantiomers of metal complexes",
abstract = "We report herein the identification of an immunomodulatory metal-based complex 1 as a direct inhibitor of TLR1/2 heterodimerization. Both enantiomers of complex 1 selectively suppressed TNF-α and TLR1/2 heterodimerization in Pam3CSK4-induced macrophages, with Λ-1 being more potent than Δ-1. Moreover, the complexes inhibited NF-κB transduction via the modulation of TLR1/2 signaling. To our knowledge, complex 1 is the first metal-based inhibitor of TLR1/2 heterodimerization reported to date.",
author = "Liu, \{Li Juan\} and Wanhe Wang and Zhangfeng Zhong and Sheng Lin and Lihua Lu and Wang, \{Yi Tao\} and Ma, \{Dik Lung\} and Leung, \{Chung Hang\}",
note = "Funding Information: This work is supported by Hong Kong Baptist University (FRG2/15-16/002), the Health and Medical Research Fund (HMRF/14130522), the Research Grants Council (HKBU/201811, HKBU/204612, and HKBU/201913), the French National Research Agency/Research Grants Council Joint Research Scheme (A-HKBU201/12; Oligoswitch ANR-12-IS07-0001), National Natural Science Foundation of China (21575121), Guangdong Province Natural Science Foundation (2015A030313816), Hong Kong Baptist University Century Club Sponsorship Scheme 2016, Interdisciplinary Research Matching Scheme (RC-IRMS/14-15/ 06), the Science and Technology Development Fund, Macao SAR (098/2014/A2), the University of Macau (MYRG2015-00137ICMS-QRCM and MRG044/LCH/2015/ICMS). Publisher copyright: {\textcopyright}The Royal Society of Chemistry 2016",
year = "2016",
month = oct,
day = "25",
doi = "10.1039/c6cc06155a",
language = "English",
volume = "52",
pages = "12278--12281",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "83",
}