Inhibition of TLR1/2 dimerization by enantiomers of metal complexes

Li Juan Liu, Wanhe Wang, Zhangfeng Zhong, Sheng Lin, Lihua Lu, Yi Tao Wang, Edmond Dik Lung MA*, Chung Hang Leung

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

We report herein the identification of an immunomodulatory metal-based complex 1 as a direct inhibitor of TLR1/2 heterodimerization. Both enantiomers of complex 1 selectively suppressed TNF-α and TLR1/2 heterodimerization in Pam3CSK4-induced macrophages, with Λ-1 being more potent than Δ-1. Moreover, the complexes inhibited NF-κB transduction via the modulation of TLR1/2 signaling. To our knowledge, complex 1 is the first metal-based inhibitor of TLR1/2 heterodimerization reported to date.

Original languageEnglish
Pages (from-to)12278-12281
Number of pages4
JournalChemical Communications
Volume52
Issue number83
DOIs
Publication statusPublished - 2016

Scopus Subject Areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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