Inhibition of PI3K/Akt signaling pathway is involved in the inhibitory effects of luteolin-plus-scoparone on the hyperproliferation of fibroblast-like synoviocytes

Keyphrases

• Abnormal Proliferation 8%
• Akt Phosphorylation 8%
• Anti-rheumatoid Arthritis 41%
• Autoimmune Disease 8%
• Cell Proliferation Assay 8%
• Chinese Herbal Formula 8%
• Chronic Inflammation 8%
• Collagen-induced Arthritis Rat 8%
• Coumarin 8%
• Disease-associated 8%
• Drug Combination 8%
• Drug Interactions 25%
• Effective Compounds 8%
• Enhanced Migration 8%
• Fibroblast-like 100%
• Flavones 8%
• Herbal Drugs 8%
• Highly Effective 8%
• Hyperproliferation 100%
• In Vitro Effect 8%
• Inflammation 8%
• Inhibitory Effect 100%
• Interaction Value 16%
• Lonicerae Japonicae Flos 16%
• Luteolin 100%
• Multi-target 8%
• Network Pharmacology 8%
• NF-κB Pathway 8%
• Pathogenic Pathways 8%
• Pathogenic Role 8%
• Pharmacological Data 8%
• PI3K-Akt Pathway 100%
• Proliferation Migration 8%
• Rheumatoid Arthritis 100%
• Rosa multiflora 16%
• Scoparone 100%
• Synergism 8%
• Synergistic Effect 16%
• Synovial Hyperplasia 8%
• Synoviocytes 100%
• Toll-like Receptor 4 (TLR4) 8%
• Traditional Chinese Medicine 8%
• Tumor-like 8%
• Western Blotting 8%

Pharmacology, Toxicology and Pharmaceutical Science

• Autoimmune Disease 5%
• Chronic Inflammation 5%
• Collagen-Induced Arthritis 5%
• Combination Drug 5%
• Coumarin 5%
• Drug Interaction 17%
• Flavone 5%
• Herbaceous Agent 5%
• Hyperplasia 5%
• Inflammation 5%
• Inflammatory Arthritis 100%
• Lonicera 11%
• Luteolin 100%
• Neoplasm 5%
• Network Pharmacology 5%
• Rheumatoid Arthritis 100%
• Scoparone 100%
• Side Effect 5%
• Synergism 5%
• Toll Like Receptor 4 5%
• Traditional Chinese Medicine 11%
• Tumor Necrosis Factor 17%
• Western Blot 5%