@article{152193c42e15459b9614ace001057c5b,
title = "Inhibition of Janus kinase 2 by cyclometalated rhodium complexes",
abstract = "Cyclometalated rhodium complexes were synthesized and evaluated as JAK2 metal-based inhibitors. Complexes 1 and 2 inhibited JAK2 enzyme phosphorylation activity, reduced JAK2 autophosphorylation in cellulo and exhibited cytotoxicity towards HEL cancer cells. To our knowledge, these are the first two examples of metal-based inhibitors of JAK2.",
author = "Leung, {Chung Hang} and Hui Yang and Ma, {Victor Pui Yan} and Chan, {Daniel Shiu Hin} and Zhong, {Hai Jing} and Li, {Ying Wei} and FONG, {David W F} and MA, {Edmond Dik Lung}",
note = "This work is supported by Hong Kong Baptist University (FRG2/10-11/008 and FRG2/11-12/009), Environment and Conservation Fund (ECF Project 3/2010), Centre for Cancer and Inflammation Research, School of Chinese Medicine (CCIRSCM, HKBU), the Research Fund for the Control of Infectious Diseases (RFCID/11101212) and the Research Grants Council (HKBU/201811) and the University of Macau (Start-up Research Grant to C.-H. Leung).",
year = "2012",
month = jun,
doi = "10.1039/c2md00306f",
language = "English",
volume = "3",
pages = "696--698",
journal = "MedChemComm",
issn = "2040-2503",
publisher = "Royal Society of Chemistry",
number = "6",
}
