Inhibition of Janus kinase 2 by cyclometalated rhodium complexes

Chung Hang Leung; Hui Yang; Victor Pui Yan Ma; Daniel Shiu Hin Chan; Hai Jing Zhong; Ying Wei Li; David W F FONG; Edmond Dik Lung MA

doi:10.1039/c2md00306f

Inhibition of Janus kinase 2 by cyclometalated rhodium complexes

Chung Hang Leung^*
, Hui Yang
, Victor Pui Yan Ma
, Daniel Shiu Hin Chan
, Hai Jing Zhong
, Ying Wei Li
, David W F FONG
, Edmond Dik Lung MA

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

30 Citations (Scopus)

Abstract

Cyclometalated rhodium complexes were synthesized and evaluated as JAK2 metal-based inhibitors. Complexes 1 and 2 inhibited JAK2 enzyme phosphorylation activity, reduced JAK2 autophosphorylation in cellulo and exhibited cytotoxicity towards HEL cancer cells. To our knowledge, these are the first two examples of metal-based inhibitors of JAK2.

Original language	English
Pages (from-to)	696-698
Number of pages	3
Journal	MedChemComm
Volume	3
Issue number	6
DOIs	https://doi.org/10.1039/c2md00306f
Publication status	Published - Jun 2012

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10.1039/c2md00306f

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title = "Inhibition of Janus kinase 2 by cyclometalated rhodium complexes",

abstract = "Cyclometalated rhodium complexes were synthesized and evaluated as JAK2 metal-based inhibitors. Complexes 1 and 2 inhibited JAK2 enzyme phosphorylation activity, reduced JAK2 autophosphorylation in cellulo and exhibited cytotoxicity towards HEL cancer cells. To our knowledge, these are the first two examples of metal-based inhibitors of JAK2.",

author = "Leung, \{Chung Hang\} and Hui Yang and Ma, \{Victor Pui Yan\} and Chan, \{Daniel Shiu Hin\} and Zhong, \{Hai Jing\} and Li, \{Ying Wei\} and FONG, \{David W F\} and MA, \{Edmond Dik Lung\}",

note = "This work is supported by Hong Kong Baptist University (FRG2/10-11/008 and FRG2/11-12/009), Environment and Conservation Fund (ECF Project 3/2010), Centre for Cancer and Inflammation Research, School of Chinese Medicine (CCIRSCM, HKBU), the Research Fund for the Control of Infectious Diseases (RFCID/11101212) and the Research Grants Council (HKBU/201811) and the University of Macau (Start-up Research Grant to C.-H. Leung).",

year = "2012",

month = jun,

doi = "10.1039/c2md00306f",

language = "English",

volume = "3",

pages = "696--698",

journal = "MedChemComm",

issn = "2040-2503",

publisher = "Royal Society of Chemistry",

number = "6",

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T1 - Inhibition of Janus kinase 2 by cyclometalated rhodium complexes

AU - Leung, Chung Hang

AU - Yang, Hui

AU - Ma, Victor Pui Yan

AU - Chan, Daniel Shiu Hin

AU - Zhong, Hai Jing

AU - Li, Ying Wei

AU - FONG, David W F

AU - MA, Edmond Dik Lung

N1 - This work is supported by Hong Kong Baptist University (FRG2/10-11/008 and FRG2/11-12/009), Environment and Conservation Fund (ECF Project 3/2010), Centre for Cancer and Inflammation Research, School of Chinese Medicine (CCIRSCM, HKBU), the Research Fund for the Control of Infectious Diseases (RFCID/11101212) and the Research Grants Council (HKBU/201811) and the University of Macau (Start-up Research Grant to C.-H. Leung).

PY - 2012/6

Y1 - 2012/6

N2 - Cyclometalated rhodium complexes were synthesized and evaluated as JAK2 metal-based inhibitors. Complexes 1 and 2 inhibited JAK2 enzyme phosphorylation activity, reduced JAK2 autophosphorylation in cellulo and exhibited cytotoxicity towards HEL cancer cells. To our knowledge, these are the first two examples of metal-based inhibitors of JAK2.

AB - Cyclometalated rhodium complexes were synthesized and evaluated as JAK2 metal-based inhibitors. Complexes 1 and 2 inhibited JAK2 enzyme phosphorylation activity, reduced JAK2 autophosphorylation in cellulo and exhibited cytotoxicity towards HEL cancer cells. To our knowledge, these are the first two examples of metal-based inhibitors of JAK2.

UR - https://www.scopus.com/pages/publications/84865851117

U2 - 10.1039/c2md00306f

DO - 10.1039/c2md00306f

M3 - Journal article

AN - SCOPUS:84865851117

SN - 2040-2503

VL - 3

SP - 696

EP - 698

JO - MedChemComm

JF - MedChemComm

IS - 6

ER -

Inhibition of Janus kinase 2 by cyclometalated rhodium complexes

Abstract

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