Inhibition of Janus kinase 2 by cyclometalated rhodium complexes

Chung Hang Leung; Hui Yang; Victor Pui Yan Ma; Daniel Shiu Hin Chan; Hai Jing Zhong; Ying Wei Li; David W F FONG; Edmond Dik Lung MA

doi:10.1039/c2md00306f

Inhibition of Janus kinase 2 by cyclometalated rhodium complexes

Chung Hang Leung^*, Hui Yang, Victor Pui Yan Ma, Daniel Shiu Hin Chan, Hai Jing Zhong, Ying Wei Li, David W F FONG, Edmond Dik Lung MA

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Cyclometalated rhodium complexes were synthesized and evaluated as JAK2 metal-based inhibitors. Complexes 1 and 2 inhibited JAK2 enzyme phosphorylation activity, reduced JAK2 autophosphorylation in cellulo and exhibited cytotoxicity towards HEL cancer cells. To our knowledge, these are the first two examples of metal-based inhibitors of JAK2.

Original language	English
Pages (from-to)	696-698
Number of pages	3
Journal	MedChemComm
Volume	3
Issue number	6
DOIs	https://doi.org/10.1039/c2md00306f
Publication status	Published - Jun 2012

Scopus Subject Areas

Biochemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1039/c2md00306f

Cite this

@article{152193c42e15459b9614ace001057c5b,

title = "Inhibition of Janus kinase 2 by cyclometalated rhodium complexes",

abstract = "Cyclometalated rhodium complexes were synthesized and evaluated as JAK2 metal-based inhibitors. Complexes 1 and 2 inhibited JAK2 enzyme phosphorylation activity, reduced JAK2 autophosphorylation in cellulo and exhibited cytotoxicity towards HEL cancer cells. To our knowledge, these are the first two examples of metal-based inhibitors of JAK2.",

author = "Leung, {Chung Hang} and Hui Yang and Ma, {Victor Pui Yan} and Chan, {Daniel Shiu Hin} and Zhong, {Hai Jing} and Li, {Ying Wei} and FONG, {David W F} and MA, {Edmond Dik Lung}",

year = "2012",

month = jun,

doi = "10.1039/c2md00306f",

language = "English",

volume = "3",

pages = "696--698",

journal = "MedChemComm",

issn = "2040-2503",

publisher = "Royal Society of Chemistry",

number = "6",

}

TY - JOUR

T1 - Inhibition of Janus kinase 2 by cyclometalated rhodium complexes

AU - Leung, Chung Hang

AU - Yang, Hui

AU - Ma, Victor Pui Yan

AU - Chan, Daniel Shiu Hin

AU - Zhong, Hai Jing

AU - Li, Ying Wei

AU - FONG, David W F

AU - MA, Edmond Dik Lung

PY - 2012/6

Y1 - 2012/6

N2 - Cyclometalated rhodium complexes were synthesized and evaluated as JAK2 metal-based inhibitors. Complexes 1 and 2 inhibited JAK2 enzyme phosphorylation activity, reduced JAK2 autophosphorylation in cellulo and exhibited cytotoxicity towards HEL cancer cells. To our knowledge, these are the first two examples of metal-based inhibitors of JAK2.

AB - Cyclometalated rhodium complexes were synthesized and evaluated as JAK2 metal-based inhibitors. Complexes 1 and 2 inhibited JAK2 enzyme phosphorylation activity, reduced JAK2 autophosphorylation in cellulo and exhibited cytotoxicity towards HEL cancer cells. To our knowledge, these are the first two examples of metal-based inhibitors of JAK2.

UR - http://www.scopus.com/inward/record.url?scp=84865851117&partnerID=8YFLogxK

U2 - 10.1039/c2md00306f

DO - 10.1039/c2md00306f

M3 - Article

AN - SCOPUS:84865851117

SN - 2040-2503

VL - 3

SP - 696

EP - 698

JO - MedChemComm

JF - MedChemComm

IS - 6

ER -

Inhibition of Janus kinase 2 by cyclometalated rhodium complexes

Abstract

Scopus Subject Areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this