Inhibition of Janus kinase 2 by cyclometalated rhodium complexes

Chung Hang Leung; Hui Yang; Victor Pui Yan Ma; Daniel Shiu Hin Chan; Hai Jing Zhong; Ying Wei Li; David W F FONG; Edmond Dik Lung MA

doi:10.1039/c2md00306f

Inhibition of Janus kinase 2 by cyclometalated rhodium complexes

Chung Hang Leung^*, Hui Yang, Victor Pui Yan Ma, Daniel Shiu Hin Chan, Hai Jing Zhong, Ying Wei Li, David W F FONG, Edmond Dik Lung MA

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

28 Citations (Scopus)

Abstract

Cyclometalated rhodium complexes were synthesized and evaluated as JAK2 metal-based inhibitors. Complexes 1 and 2 inhibited JAK2 enzyme phosphorylation activity, reduced JAK2 autophosphorylation in cellulo and exhibited cytotoxicity towards HEL cancer cells. To our knowledge, these are the first two examples of metal-based inhibitors of JAK2.

Original language	English
Pages (from-to)	696-698
Number of pages	3
Journal	MedChemComm
Volume	3
Issue number	6
DOIs	https://doi.org/10.1039/c2md00306f
Publication status	Published - Jun 2012

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10.1039/c2md00306f

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title = "Inhibition of Janus kinase 2 by cyclometalated rhodium complexes",

abstract = "Cyclometalated rhodium complexes were synthesized and evaluated as JAK2 metal-based inhibitors. Complexes 1 and 2 inhibited JAK2 enzyme phosphorylation activity, reduced JAK2 autophosphorylation in cellulo and exhibited cytotoxicity towards HEL cancer cells. To our knowledge, these are the first two examples of metal-based inhibitors of JAK2.",

author = "Leung, {Chung Hang} and Hui Yang and Ma, {Victor Pui Yan} and Chan, {Daniel Shiu Hin} and Zhong, {Hai Jing} and Li, {Ying Wei} and FONG, {David W F} and MA, {Edmond Dik Lung}",

year = "2012",

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doi = "10.1039/c2md00306f",

language = "English",

volume = "3",

pages = "696--698",

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issn = "2040-2503",

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T1 - Inhibition of Janus kinase 2 by cyclometalated rhodium complexes

AU - Leung, Chung Hang

AU - Yang, Hui

AU - Ma, Victor Pui Yan

AU - Chan, Daniel Shiu Hin

AU - Zhong, Hai Jing

AU - Li, Ying Wei

AU - FONG, David W F

AU - MA, Edmond Dik Lung

PY - 2012/6

Y1 - 2012/6

N2 - Cyclometalated rhodium complexes were synthesized and evaluated as JAK2 metal-based inhibitors. Complexes 1 and 2 inhibited JAK2 enzyme phosphorylation activity, reduced JAK2 autophosphorylation in cellulo and exhibited cytotoxicity towards HEL cancer cells. To our knowledge, these are the first two examples of metal-based inhibitors of JAK2.

AB - Cyclometalated rhodium complexes were synthesized and evaluated as JAK2 metal-based inhibitors. Complexes 1 and 2 inhibited JAK2 enzyme phosphorylation activity, reduced JAK2 autophosphorylation in cellulo and exhibited cytotoxicity towards HEL cancer cells. To our knowledge, these are the first two examples of metal-based inhibitors of JAK2.

UR - http://www.scopus.com/inward/record.url?scp=84865851117&partnerID=8YFLogxK

U2 - 10.1039/c2md00306f

DO - 10.1039/c2md00306f

M3 - Journal article

AN - SCOPUS:84865851117

SN - 2040-2503

VL - 3

SP - 696

EP - 698

JO - MedChemComm

JF - MedChemComm

IS - 6

ER -

Inhibition of Janus kinase 2 by cyclometalated rhodium complexes

Abstract

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