Inhibition of Janus kinase 2 by cyclometalated rhodium complexes

Chung Hang Leung*, Hui Yang, Victor Pui Yan Ma, Daniel Shiu Hin Chan, Hai Jing Zhong, Ying Wei Li, David W F FONG, Edmond Dik Lung MA

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Cyclometalated rhodium complexes were synthesized and evaluated as JAK2 metal-based inhibitors. Complexes 1 and 2 inhibited JAK2 enzyme phosphorylation activity, reduced JAK2 autophosphorylation in cellulo and exhibited cytotoxicity towards HEL cancer cells. To our knowledge, these are the first two examples of metal-based inhibitors of JAK2.

Original languageEnglish
Pages (from-to)696-698
Number of pages3
JournalMedChemComm
Volume3
Issue number6
DOIs
Publication statusPublished - Jun 2012

Scopus Subject Areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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