Inhibition of beta-amyloid peptide aggregation by multifunctional carbazole-based fluorophores

Wanggui Yang; Yi Wong; Olivia T.W. Ng; Li Ping Bai; Daniel W J KWONG; Ya Ke; Zhi Hong JIANG; Hung Wing LI; Kin Lam YUNG; Ricky M S WONG

doi:10.1002/anie.201104150

Inhibition of beta-amyloid peptide aggregation by multifunctional carbazole-based fluorophores

Wanggui Yang
, Yi Wong
, Olivia T.W. Ng
, Li Ping Bai
, Daniel W J KWONG
, Ya Ke
, Zhi Hong JIANG
, Hung Wing LI^*
, Kin Lam YUNG^*
, Ricky M S WONG^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

135 Citations (Scopus)

Abstract

Stopping aggregation: Carbazole-based cyanine fluorophores bind selectively to the Aβ _(1-40) peptide and its aggregates which are responsible for causing Alzheimer's disease. One of these fluorophores, SLOH, exerts a strong inhibitory effect on Aβ _(1-40) fibrillogenesis (see scheme) and can pass through the blood-brain barrier making it a potential therapeutic agent for Alzheimer's disease.

Original language	English
Pages (from-to)	1804-1810
Number of pages	7
Journal	Angewandte Chemie. International Edition
Volume	51
Issue number	8
Early online date	15 Nov 2011
DOIs	https://doi.org/10.1002/anie.201104150
Publication status	Published - 20 Feb 2012

User-Defined Keywords

Alzheimer's disease
beta-amyloid peptide
fluorophores
inhibitors

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10.1002/anie.201104150

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title = "Inhibition of beta-amyloid peptide aggregation by multifunctional carbazole-based fluorophores",

abstract = "Stopping aggregation: Carbazole-based cyanine fluorophores bind selectively to the Aβ (1-40) peptide and its aggregates which are responsible for causing Alzheimer's disease. One of these fluorophores, SLOH, exerts a strong inhibitory effect on Aβ (1-40) fibrillogenesis (see scheme) and can pass through the blood-brain barrier making it a potential therapeutic agent for Alzheimer's disease.",

keywords = "Alzheimer's disease, beta-amyloid peptide, fluorophores, inhibitors",

author = "Wanggui Yang and Yi Wong and Ng, \{Olivia T.W.\} and Bai, \{Li Ping\} and KWONG, \{Daniel W J\} and Ya Ke and JIANG, \{Zhi Hong\} and LI, \{Hung Wing\} and YUNG, \{Kin Lam\} and WONG, \{Ricky M S\}",

note = "This work was financially supported by the Research Grant Council of the Hong Kong Special Administrative Region, P. R. China(HKBU201208 for H.W.L.; HKBU262107 and HKBU262210 for K.K.L.Y.; HKBU202408 for M.S.W.; and, HKBU2607/09M for Z.H.J.).K.K.L.Y. also thanks the Hong Kong Baptist University Research Committee (RC/AOE/08-09/02). We thank Mr. Chun-Tak Lau at Chemistry Department, Hong Kong University of Science and Technology for assistance with CD measurements. The FEI-Technai G2 TEM used in this work was supported by the Centre for Surface Analysis and Research (CSAR) with funding from the Special Equipment Grant from the University Grant Committee of the Hong Kong Special Administrative Region, China(SEG\_HKBU06).",

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doi = "10.1002/anie.201104150",

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T1 - Inhibition of beta-amyloid peptide aggregation by multifunctional carbazole-based fluorophores

AU - Yang, Wanggui

AU - Wong, Yi

AU - Ng, Olivia T.W.

AU - Bai, Li Ping

AU - KWONG, Daniel W J

AU - Ke, Ya

AU - JIANG, Zhi Hong

AU - LI, Hung Wing

AU - YUNG, Kin Lam

AU - WONG, Ricky M S

N1 - This work was financially supported by the Research Grant Council of the Hong Kong Special Administrative Region, P. R. China(HKBU201208 for H.W.L.; HKBU262107 and HKBU262210 for K.K.L.Y.; HKBU202408 for M.S.W.; and, HKBU2607/09M for Z.H.J.).K.K.L.Y. also thanks the Hong Kong Baptist University Research Committee (RC/AOE/08-09/02). We thank Mr. Chun-Tak Lau at Chemistry Department, Hong Kong University of Science and Technology for assistance with CD measurements. The FEI-Technai G2 TEM used in this work was supported by the Centre for Surface Analysis and Research (CSAR) with funding from the Special Equipment Grant from the University Grant Committee of the Hong Kong Special Administrative Region, China(SEG_HKBU06).

PY - 2012/2/20

Y1 - 2012/2/20

N2 - Stopping aggregation: Carbazole-based cyanine fluorophores bind selectively to the Aβ (1-40) peptide and its aggregates which are responsible for causing Alzheimer's disease. One of these fluorophores, SLOH, exerts a strong inhibitory effect on Aβ (1-40) fibrillogenesis (see scheme) and can pass through the blood-brain barrier making it a potential therapeutic agent for Alzheimer's disease.

AB - Stopping aggregation: Carbazole-based cyanine fluorophores bind selectively to the Aβ (1-40) peptide and its aggregates which are responsible for causing Alzheimer's disease. One of these fluorophores, SLOH, exerts a strong inhibitory effect on Aβ (1-40) fibrillogenesis (see scheme) and can pass through the blood-brain barrier making it a potential therapeutic agent for Alzheimer's disease.

KW - Alzheimer's disease

KW - beta-amyloid peptide

KW - fluorophores

KW - inhibitors

UR - https://www.scopus.com/pages/publications/84863146128

U2 - 10.1002/anie.201104150

DO - 10.1002/anie.201104150

M3 - Journal article

AN - SCOPUS:84863146128

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JO - Angewandte Chemie. International Edition

JF - Angewandte Chemie. International Edition

IS - 8

ER -

Inhibition of beta-amyloid peptide aggregation by multifunctional carbazole-based fluorophores

Abstract

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