Inhibition of beta-amyloid peptide aggregation by multifunctional carbazole-based fluorophores

Wanggui Yang, Yi Wong, Olivia T.W. Ng, Li Ping Bai, Daniel W J KWONG, Ya Ke, Zhi Hong JIANG, Hung Wing LI*, Kin Lam YUNG, Ricky M S WONG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

86 Citations (Scopus)

Abstract

Stopping aggregation: Carbazole-based cyanine fluorophores bind selectively to the Aβ (1-40) peptide and its aggregates which are responsible for causing Alzheimer's disease. One of these fluorophores, SLOH, exerts a strong inhibitory effect on Aβ (1-40) fibrillogenesis (see scheme) and can pass through the blood-brain barrier making it a potential therapeutic agent for Alzheimer's disease.

Original languageEnglish
Pages (from-to)1804-1810
Number of pages7
JournalAngewandte Chemie. International Edition
Volume51
Issue number8
DOIs
Publication statusPublished - 20 Feb 2012

Scopus Subject Areas

  • Catalysis
  • Chemistry(all)

User-Defined Keywords

  • Alzheimer's disease
  • beta-amyloid peptide
  • fluorophores
  • inhibitors

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