Stopping aggregation: Carbazole-based cyanine fluorophores bind selectively to the Aβ (1-40) peptide and its aggregates which are responsible for causing Alzheimer's disease. One of these fluorophores, SLOH, exerts a strong inhibitory effect on Aβ (1-40) fibrillogenesis (see scheme) and can pass through the blood-brain barrier making it a potential therapeutic agent for Alzheimer's disease.
|Number of pages||7|
|Journal||Angewandte Chemie. International Edition|
|Early online date||15 Nov 2011|
|Publication status||Published - 20 Feb 2012|
Scopus Subject Areas
- Alzheimer's disease
- beta-amyloid peptide