Inhibition of beta-amyloid peptide aggregation by multifunctional carbazole-based fluorophores

Wanggui Yang; Yi Wong; Olivia T.W. Ng; Li Ping Bai; Daniel W J KWONG; Ya Ke; Zhi Hong JIANG; Hung Wing LI; Kin Lam YUNG; Ricky M S WONG

doi:10.1002/anie.201104150

Inhibition of beta-amyloid peptide aggregation by multifunctional carbazole-based fluorophores

Wanggui Yang, Yi Wong, Olivia T.W. Ng, Li Ping Bai, Daniel W J KWONG, Ya Ke, Zhi Hong JIANG, Hung Wing LI^*, Kin Lam YUNG^*, Ricky M S WONG^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

124 Citations (Scopus)

Abstract

Stopping aggregation: Carbazole-based cyanine fluorophores bind selectively to the Aβ _(1-40) peptide and its aggregates which are responsible for causing Alzheimer's disease. One of these fluorophores, SLOH, exerts a strong inhibitory effect on Aβ _(1-40) fibrillogenesis (see scheme) and can pass through the blood-brain barrier making it a potential therapeutic agent for Alzheimer's disease.

Original language	English
Pages (from-to)	1804-1810
Number of pages	7
Journal	Angewandte Chemie. International Edition
Volume	51
Issue number	8
Early online date	15 Nov 2011
DOIs	https://doi.org/10.1002/anie.201104150
Publication status	Published - 20 Feb 2012

Scopus Subject Areas

Catalysis
Chemistry(all)

User-Defined Keywords

Alzheimer's disease
beta-amyloid peptide
fluorophores
inhibitors

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10.1002/anie.201104150

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abstract = "Stopping aggregation: Carbazole-based cyanine fluorophores bind selectively to the Aβ (1-40) peptide and its aggregates which are responsible for causing Alzheimer's disease. One of these fluorophores, SLOH, exerts a strong inhibitory effect on Aβ (1-40) fibrillogenesis (see scheme) and can pass through the blood-brain barrier making it a potential therapeutic agent for Alzheimer's disease.",

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AU - Wong, Yi

AU - Ng, Olivia T.W.

AU - Bai, Li Ping

AU - KWONG, Daniel W J

AU - Ke, Ya

AU - JIANG, Zhi Hong

AU - LI, Hung Wing

AU - YUNG, Kin Lam

AU - WONG, Ricky M S

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AB - Stopping aggregation: Carbazole-based cyanine fluorophores bind selectively to the Aβ (1-40) peptide and its aggregates which are responsible for causing Alzheimer's disease. One of these fluorophores, SLOH, exerts a strong inhibitory effect on Aβ (1-40) fibrillogenesis (see scheme) and can pass through the blood-brain barrier making it a potential therapeutic agent for Alzheimer's disease.

KW - Alzheimer's disease

KW - beta-amyloid peptide

KW - fluorophores

KW - inhibitors

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JF - Angewandte Chemie. International Edition

IS - 8

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Inhibition of beta-amyloid peptide aggregation by multifunctional carbazole-based fluorophores

Abstract

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