Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes

Lihua Lu; Hai Jing Zhong; Modi Wang; See Lok Ho; Hung Wing LI; Chung Hang Leung; Edmond Dik Lung MA

doi:10.1038/srep14619

Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes

Lihua Lu
, Hai Jing Zhong
, Modi Wang
, See Lok Ho
, Hung Wing LI^*
, Chung Hang Leung^*
, Edmond Dik Lung MA^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

44 Citations (Scopus)

114 Downloads (Pure)

Abstract

We report herein the application of kinetically inert luminescent iridium(III) complexes as dual inhibitors and probes of beta-amyloid fibrillogenesis. These iridium(III) complexes inhibited Aβ 1-40 peptide aggregation in vitro, and protected against Aβ-induced cytotoxicity in neuronal cells. Furthermore, the complexes differentiated between the aggregated and unaggregated forms of Aβ 1-40 peptide on the basis of their emission response.

Original language	English
Article number	14619
Journal	Scientific Reports
Volume	5
DOIs	https://doi.org/10.1038/srep14619
Publication status	Published - 30 Sept 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1038/srep14619

Full TextFinal published version, 1.11 MB

Cite this

@article{9be339e8890742c89b9dafca0f9b2e0b,

title = "Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes",

abstract = "We report herein the application of kinetically inert luminescent iridium(III) complexes as dual inhibitors and probes of beta-amyloid fibrillogenesis. These iridium(III) complexes inhibited Aβ 1-40 peptide aggregation in vitro, and protected against Aβ-induced cytotoxicity in neuronal cells. Furthermore, the complexes differentiated between the aggregated and unaggregated forms of Aβ 1-40 peptide on the basis of their emission response.",

author = "Lihua Lu and Zhong, \{Hai Jing\} and Modi Wang and Ho, \{See Lok\} and LI, \{Hung Wing\} and Leung, \{Chung Hang\} and MA, \{Edmond Dik Lung\}",

note = "Funding Information: This work is supported by Hong Kong Baptist University (FRG2/14-15/004), the Health and Medical Research Fund (HMRF/13121482 and HMRF/14130522), the Research Grants Council (HKBU/201811, HKBU/204612 and HKBU/201913), the French National Research Agency/Research Grants Council Joint Research Scheme (A-HKBU201/12), State Key Laboratory of Environmental and Biological Analysis Research Grant (SKLP-14-15-P001), National Natural Science Foundation of China (21575121), Guangdong Province Natural Science Foundation (2015A030313816), Hong Kong Baptist University Century Club Sponsorship Scheme 2015, Interdisciplinary Research Matching Scheme (RC-IRMS/14-15/06), the State Key Laboratory of Synthetic Chemistry, the Science and Technology Development Fund, Macao SAR (103/2012/A3 and 098/2014/A2) and the University of Macau (MYRG091(Y3-L2)-ICMS12-LCH, MYRG2015-00137-ICMS-QRCM and MRG023/LCH/2013/ICMS).",

year = "2015",

month = sep,

day = "30",

doi = "10.1038/srep14619",

language = "English",

volume = "5",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Portfolio",

}

TY - JOUR

T1 - Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes

AU - Lu, Lihua

AU - Zhong, Hai Jing

AU - Wang, Modi

AU - Ho, See Lok

AU - LI, Hung Wing

AU - Leung, Chung Hang

AU - MA, Edmond Dik Lung

N1 - Funding Information: This work is supported by Hong Kong Baptist University (FRG2/14-15/004), the Health and Medical Research Fund (HMRF/13121482 and HMRF/14130522), the Research Grants Council (HKBU/201811, HKBU/204612 and HKBU/201913), the French National Research Agency/Research Grants Council Joint Research Scheme (A-HKBU201/12), State Key Laboratory of Environmental and Biological Analysis Research Grant (SKLP-14-15-P001), National Natural Science Foundation of China (21575121), Guangdong Province Natural Science Foundation (2015A030313816), Hong Kong Baptist University Century Club Sponsorship Scheme 2015, Interdisciplinary Research Matching Scheme (RC-IRMS/14-15/06), the State Key Laboratory of Synthetic Chemistry, the Science and Technology Development Fund, Macao SAR (103/2012/A3 and 098/2014/A2) and the University of Macau (MYRG091(Y3-L2)-ICMS12-LCH, MYRG2015-00137-ICMS-QRCM and MRG023/LCH/2013/ICMS).

PY - 2015/9/30

Y1 - 2015/9/30

N2 - We report herein the application of kinetically inert luminescent iridium(III) complexes as dual inhibitors and probes of beta-amyloid fibrillogenesis. These iridium(III) complexes inhibited Aβ 1-40 peptide aggregation in vitro, and protected against Aβ-induced cytotoxicity in neuronal cells. Furthermore, the complexes differentiated between the aggregated and unaggregated forms of Aβ 1-40 peptide on the basis of their emission response.

AB - We report herein the application of kinetically inert luminescent iridium(III) complexes as dual inhibitors and probes of beta-amyloid fibrillogenesis. These iridium(III) complexes inhibited Aβ 1-40 peptide aggregation in vitro, and protected against Aβ-induced cytotoxicity in neuronal cells. Furthermore, the complexes differentiated between the aggregated and unaggregated forms of Aβ 1-40 peptide on the basis of their emission response.

UR - https://www.scopus.com/pages/publications/84942897293

U2 - 10.1038/srep14619

DO - 10.1038/srep14619

M3 - Journal article

C2 - 26419607

AN - SCOPUS:84942897293

SN - 2045-2322

VL - 5

JO - Scientific Reports

JF - Scientific Reports

M1 - 14619

ER -

Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this