Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes

Lihua Lu, Hai Jing Zhong, Modi Wang, See Lok Ho, Hung Wing LI*, Chung Hang Leung, Edmond Dik Lung MA

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

We report herein the application of kinetically inert luminescent iridium(III) complexes as dual inhibitors and probes of beta-amyloid fibrillogenesis. These iridium(III) complexes inhibited Aβ 1-40 peptide aggregation in vitro, and protected against Aβ-induced cytotoxicity in neuronal cells. Furthermore, the complexes differentiated between the aggregated and unaggregated forms of Aβ 1-40 peptide on the basis of their emission response.

Original languageEnglish
Article number14619
JournalScientific Reports
Volume5
DOIs
Publication statusPublished - 30 Sep 2015

Scopus Subject Areas

  • General

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