TY - JOUR
T1 - Inflammatory Processes: Key Mediators of Oncogenesis and Progression in Pancreatic Ductal Adenocarcinoma (PDAC)
AU - Yang, Liu
AU - Qiao, Shuangying
AU - Zhang, Ge
AU - Lu, Aiping
AU - Li, Fangfei
N1 - This study was supported by the Hong Kong General Research Fund (12101018, 12102518, 12100719), the Interdisciplinary Research Matching Scheme Hong Kong Baptist University (RCIRMS/15-16/01), the Technology Innovation Strategy Special Fund (Guangdong-Hong Kong-Macau Joint Lab, No: 2020B1212030006), the HK Theme-based Scheme (T12-201/20-R), and the Nature science Foundation of Shandong province (ZR2020QH219).
Copyright:
© 2024 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2024/10/12
Y1 - 2024/10/12
N2 - Associations between inflammation and cancer were first discovered approximately 160 years ago by Rudolf Virchow, who observed that tumors were infiltrated with inflammatory cells, and defined inflammation as a pathological condition. Inflammation has now emerged as one of the key mediators in oncogenesis and tumor progression, including pancreatic ductal adenocarcinoma (PDAC). However, the role of inflammatory processes in cancers is complicated and controversial, and the detailed regulatory mechanisms are still unclear. This review elucidates the dynamic interplay between inflammation and immune regulation, microenvironment alteration, metabolic reprogramming, and microbiome risk factors in PDAC, committing to exploring a deeper understanding of the role of crucial inflammatory pathways and molecules for providing insights into therapeutic strategies.
AB - Associations between inflammation and cancer were first discovered approximately 160 years ago by Rudolf Virchow, who observed that tumors were infiltrated with inflammatory cells, and defined inflammation as a pathological condition. Inflammation has now emerged as one of the key mediators in oncogenesis and tumor progression, including pancreatic ductal adenocarcinoma (PDAC). However, the role of inflammatory processes in cancers is complicated and controversial, and the detailed regulatory mechanisms are still unclear. This review elucidates the dynamic interplay between inflammation and immune regulation, microenvironment alteration, metabolic reprogramming, and microbiome risk factors in PDAC, committing to exploring a deeper understanding of the role of crucial inflammatory pathways and molecules for providing insights into therapeutic strategies.
KW - immunity
KW - inflammation
KW - metabolism
KW - microbiome
KW - pancreatic ductal adenocarcinoma
KW - tumor microenvironment
UR - http://www.scopus.com/inward/record.url?scp=85207422840&partnerID=8YFLogxK
U2 - 10.3390/ijms252010991
DO - 10.3390/ijms252010991
M3 - Journal article
SN - 1661-6596
VL - 25
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 20
M1 - 10991
ER -
