Indirubin-3'-oxime as an antiviral and immunomodulatory agent in treatment of severe human influenza virus infection

MCW Chan*, RWY Chan, CKP Mok, Nai Ki MAK, Ricky N S WONG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

1. Two indirubin derivatives (indirubin-3′-oxime and E804) demonstrate strong antiviral and immunomodulatory effects on human macrophages and type-I alveolar epithelial cells after influenza H5N1 virus infection.
2. In mice infected with H5N1 virus, the use of E804 does not improve survival or weight loss but significantly reduces cytokine and chemokine expression and secretion, compared with controls.
3. Cyclin-dependent kinases pathway is involved in the antiviral and immunomodulatory effects of indirubin upon influenza H5N1 virus infection.
Original languageEnglish
Pages (from-to)S45-S47
Number of pages3
JournalHong Kong Medical Journal
Volume24
Issue number5, Suppl 6
Publication statusPublished - Oct 2018

Scopus Subject Areas

  • Medicine(all)

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