Abstract
1. Two indirubin derivatives (indirubin-3′-oxime and E804) demonstrate strong antiviral and immunomodulatory effects on human macrophages and type-I alveolar epithelial cells after influenza H5N1 virus infection.
2. In mice infected with H5N1 virus, the use of E804 does not improve survival or weight loss but significantly reduces cytokine and chemokine expression and secretion, compared with controls.
3. Cyclin-dependent kinases pathway is involved in the antiviral and immunomodulatory effects of indirubin upon influenza H5N1 virus infection.
2. In mice infected with H5N1 virus, the use of E804 does not improve survival or weight loss but significantly reduces cytokine and chemokine expression and secretion, compared with controls.
3. Cyclin-dependent kinases pathway is involved in the antiviral and immunomodulatory effects of indirubin upon influenza H5N1 virus infection.
| Original language | English |
|---|---|
| Pages (from-to) | S45-S47 |
| Number of pages | 3 |
| Journal | Hong Kong Medical Journal |
| Volume | 24 |
| Issue number | 5, Suppl 6 |
| Publication status | Published - Oct 2018 |
Scopus Subject Areas
- General Medicine