Independent self-construal mediates the association between CYP19A1 gene variant and subjective well-being

Xing Yang, Yafang Yang, Mengying Xue, Pengpeng Fang, Guomin Shen, Kejin Zhang, Xiaocai Gao, Rongjun Yu, Pingyuan Gong*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

4 Citations (Scopus)


Testosterone and estrogen are involved in self-related behavioral dispositions and experiences of subjective well-being. In this study, we investigated to what extent the aromatase (CYP19A1) gene, which encodes an enzyme in converting testosterone into estrogen, contributes to subjective well-being and in another self-related disposition: independent and interdependent self-construal. In study 1, a meta-analysis showed that the GG genotype of CYP19A1 (a G/A substitution at Val80, rs700518) was associated with higher testosterone and lower estradiol. In study 2, an empirical study of individuals with the GG (n = 115), AG (n = 286) and AA (n = 193) genotypes indicated that individuals with the GG genotype exhibited higher independent self-construal and higher subjective well-being. The association between the GG genotype of CYP19A1 Val80 and subjective well-being was mediated by the independent self-construal. Our findings reinforce the idea that personality traits such as independent self-construal explain the link between genetic variant and subjective well-being.

Original languageEnglish
Pages (from-to)205-213
Number of pages9
JournalConsciousness and Cognition
Publication statusPublished - Oct 2017

Scopus Subject Areas

  • Experimental and Cognitive Psychology
  • Developmental and Educational Psychology

User-Defined Keywords

  • Aromatase
  • Estrogen
  • Self-construal
  • Subjective well-being
  • Testosterone


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