Increased expression of EIF5A2, via hypoxia or gene amplification, contributes to metastasis and angiogenesis of esophageal squamous cell carcinoma

Keyphrases

• Hypoxia 100%
• Angiogenesis 100%
• Metastasis 100%
• OR Genes 100%
• Esophageal Squamous Cell Carcinoma 100%
• EIF5A2 100%
• Gene Amplification 100%
• Hypoxia-inducible factor-1α (HIF-1α) 35%
• Esophageal Squamous Carcinoma Cell 29%
• Knockdown 17%
• Carcinoma Cell Lines 17%
• Overexpression 11%
• Responsive Genes 11%
• Vascular Endothelial Growth Factor 11%
• Hypoxia Response 11%
• Xenograft Tumor 11%
• Survival Time 11%
• Signaling Pathway 5%
• Polymerase Chain Reaction Analysis 5%
• Quantitative PCR 5%
• Chromatin Immunoprecipitation (ChIP) 5%
• Solid Tumors 5%
• Docetaxel 5%
• Tumor 5%
• Immunohistochemical Analysis 5%
• Messenger RNA (mRNA) 5%
• Cisplatin 5%
• Luciferase Reporter 5%
• Cell Growth 5%
• Epithelial-to-mesenchymal Transition 5%
• Mouse Xenograft 5%
• Microvessels 5%
• Lymph Node 5%
• Bidirectional Regulation 5%
• Transient Transfection 5%
• Carcinoma Metastasis 5%
• Invasive Ability 5%
• Esophageal Tissue 5%
• Interfering RNA 5%
• Copy number Variation 5%
• Xenograft Mice 5%
• Fluorescence in Situ Hybridization 5%
• Nontumor 5%
• Migratory Ability 5%
• Tissue Invasion 5%
• Vector Control 5%
• Gene Copy number 5%
• Non-tumor Tissue 5%
• HIF-1α Inhibitor 5%

Medicine and Dentistry

• Angiogenesis 100%
• Hypoxia 100%
• Metastatic Carcinoma 100%
• Gene Amplification 100%
• Esophageal Squamous Cell Carcinoma 100%
• Hypoxia Inducible Factor 1 60%
• Tumor Xenograft 30%
• Esophageal Squamous Cell Carcinoma Cell Line 30%
• Vasculotropin 20%
• Survival Time 20%
• Squamous Cell Carcinoma Cell 20%
• Messenger RNA 10%
• Cell Signaling Pathway 10%
• Neoplasm 10%
• Upregulation 10%
• Real-Time Polymerase Chain Reaction 10%
• Gene Dosage 10%
• Immunohistochemistry 10%
• Microvessel 10%
• Solid Malignant Neoplasm 10%
• Cisplatin 10%
• Docetaxel 10%
• Lymph Node 10%
• Fluorescence in Situ Hybridization 10%
• Cell Growth 10%
• Transient Transfection 10%
• Vector Control 10%
• Mesenchymal-Epithelial Transition 10%
• Chromatin Immunoprecipitation 10%
• Luciferase 10%

Biochemistry, Genetics and Molecular Biology

• Angiogenesis 100%
• Hypoxia Inducible Factor 1 100%
• Gene Amplification 100%
• Vascular Endothelial Growth Factor 33%
• Survival Time 33%
• Messenger RNA 16%
• Chromatin Immunoprecipitation 16%
• Upregulation 16%
• Real-Time Polymerase Chain Reaction 16%
• RNA 16%
• Gene Dosage 16%
• Nude Mouse 16%
• Cisplatin 16%
• Luciferase 16%
• Mesenchymal-Epithelial Transition 16%
• Fluorescence in Situ Hybridization 16%
• Transient Transfection 16%
• Interaction Study 16%