A magnetic personality: Magnetofection and gene delivery have been investigated in HepG2 cells using ternary organic-inorganic hybrid nanocomposites that contain deferoxamine-coated iron oxide nanoparticles (NPs), circular plasmid DNA, and branched polyethylenimine (PEI). It was found that the cellular uptake efficacies depend on the ratio of components in PEI/DNA/NP, as assessed by Prussian staining, magnetic resonance imaging, and luciferase expression in the presence and absence of a magnet during transfection.
Scopus Subject Areas
- Organic Chemistry
- gene delivery
- imaging agents
- organic-inorganic hybrid composites