Increased efficacies in magnetofection and gene delivery to hepatocellular carcinoma cells with ternary organic-inorganic hybrid nanocomposites

Ken C F LEUNG*, Chun Pong Chak, Siu Fung Lee, Josie M.Y. Lai, Xiao Ming Zhu, Yi Xiang J. Wang, Kathy W.Y. Sham, Chi Hin Wong, Christopher H.K. Cheng

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

A magnetic personality: Magnetofection and gene delivery have been investigated in HepG2 cells using ternary organic-inorganic hybrid nanocomposites that contain deferoxamine-coated iron oxide nanoparticles (NPs), circular plasmid DNA, and branched polyethylenimine (PEI). It was found that the cellular uptake efficacies depend on the ratio of components in PEI/DNA/NP, as assessed by Prussian staining, magnetic resonance imaging, and luciferase expression in the presence and absence of a magnet during transfection.

Original languageEnglish
Pages (from-to)1760-1764
Number of pages5
JournalChemistry - An Asian Journal
Volume8
Issue number8
DOIs
Publication statusPublished - Aug 2013

Scopus Subject Areas

  • Biochemistry
  • Organic Chemistry

User-Defined Keywords

  • gene delivery
  • imaging agents
  • magnetofection
  • nanoparticles
  • organic-inorganic hybrid composites

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