Increased di-(2-ethylhexyl) phthalate exposure poses a differential risk for adult asthma clusters

Yuan Ting Hsu; Chao Chien Wu; Chin Chou Wang; Chau Chyun Sheu; Yi Hsin Yang; Ming Yen Cheng; Ruay Sheng Lai; Sum Yee Leung; Chi Cheng Lin; Yu Feng Wei; Yung Fa Lai; Meng Hsuan Cheng; Huang Chi Chen; Chih Jen Yang; Chien Jen Wang; Huei Ju Liu; Hua Ling Chen; Chih Hsing Hung; Chon Lin Lee; Ming Shyan Huang; Shau Ku Huang

doi:10.1186/s12931-024-02764-8

Increased di-(2-ethylhexyl) phthalate exposure poses a differential risk for adult asthma clusters

Yuan Ting Hsu, Chao Chien Wu, Chin Chou Wang, Chau Chyun Sheu, Yi Hsin Yang, Ming Yen Cheng, Ruay Sheng Lai, Sum Yee Leung, Chi Cheng Lin, Yu Feng Wei, Yung Fa Lai, Meng Hsuan Cheng, Huang Chi Chen, Chih Jen Yang, Chien Jen Wang, Huei Ju Liu, Hua Ling Chen, Chih Hsing Hung^*, Chon Lin Lee^*, Ming Shyan Huang^*Shau Ku Huang^*

^*Corresponding author for this work

Department of Mathematics

Research output: Contribution to journal › Journal article › peer-review

1 Citation (Scopus)

Abstract

Background: DEHP, a common plasticizer known for its hormone-disrupting properties, has been associated with asthma. However, a significant proportion of adult asthma cases are “non-atopic”, lacking a clear etiology.

Methods: In a case-control study conducted between 2011 and 2015, 365 individuals with current asthma and 235 healthy controls from Kaohsiung City were enrolled. The control group comprised individuals without asthma, Type 2 Diabetes Mellitus (T2DM), hypertension, or other respiratory/allergic conditions. The study leveraged asthma clusters (Clusters A to F) established in a prior investigation. Analysis involved the examination of urinary DEHP metabolites (MEHP and MEHHP), along with the assessment of oxidative stress, sphingolipid metabolites, and inflammatory biomarkers. Statistical analyses encompassed Spearman’s rank correlation coefficients, multiple logistic regression, and multinomial logistic regression. Results: Asthma clusters (E, D, C, F, A) exhibited significantly higher ORs of MEHHP exposures compared to the control group. When considering asthma-related comorbidities (T2DM, hypertension, or both), patients without comorbidities demonstrated significantly higher ORs of the sum of primary and secondary metabolites (MEHP + MEHHP) and MEHHP compared to those with asthma comorbidities. A consistent positive correlation between urinary HEL and DEHP metabolites was observed, but a consistent negative correlation between DEHP metabolites and selected cytokines was identified.

Conclusion: The current study reveals a heightened risk of MEHHP and MEHP + MEHHP exposure in specific asthma subgroups, emphasizing its complex relationship with asthma. The observed negative correlation with cytokines suggests a new avenue for research, warranting robust evidence from epidemiological and animal studies.

Original language	English
Article number	139
Number of pages	16
Journal	Respiratory Research
Volume	25
Issue number	1
DOIs	https://doi.org/10.1186/s12931-024-02764-8
Publication status	Published - 23 Mar 2024

User-Defined Keywords

Asthma phenotype
Comorbidities
DEHP
HEL
Inflammatory markers

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s12931-024-02764-8

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Hsu, Y. T., Wu, C. C., Wang, C. C., Sheu, C. C., Yang, Y. H., Cheng, M. Y., Lai, R. S., Leung, S. Y., Lin, C. C., Wei, Y. F., Lai, Y. F., Cheng, M. H., Chen, H. C., Yang, C. J., Wang, C. J., Liu, H. J., Chen, H. L., Hung, C. H., Lee, C. L., ... Huang, S. K. (2024). Increased di-(2-ethylhexyl) phthalate exposure poses a differential risk for adult asthma clusters. Respiratory Research, 25(1), Article 139. https://doi.org/10.1186/s12931-024-02764-8

@article{e494cb77bf8747bba47d03cebe58e4c0,

title = "Increased di-(2-ethylhexyl) phthalate exposure poses a differential risk for adult asthma clusters",

abstract = "Background: DEHP, a common plasticizer known for its hormone-disrupting properties, has been associated with asthma. However, a significant proportion of adult asthma cases are “non-atopic”, lacking a clear etiology.Methods: In a case-control study conducted between 2011 and 2015, 365 individuals with current asthma and 235 healthy controls from Kaohsiung City were enrolled. The control group comprised individuals without asthma, Type 2 Diabetes Mellitus (T2DM), hypertension, or other respiratory/allergic conditions. The study leveraged asthma clusters (Clusters A to F) established in a prior investigation. Analysis involved the examination of urinary DEHP metabolites (MEHP and MEHHP), along with the assessment of oxidative stress, sphingolipid metabolites, and inflammatory biomarkers. Statistical analyses encompassed Spearman{\textquoteright}s rank correlation coefficients, multiple logistic regression, and multinomial logistic regression. Results: Asthma clusters (E, D, C, F, A) exhibited significantly higher ORs of MEHHP exposures compared to the control group. When considering asthma-related comorbidities (T2DM, hypertension, or both), patients without comorbidities demonstrated significantly higher ORs of the sum of primary and secondary metabolites (MEHP + MEHHP) and MEHHP compared to those with asthma comorbidities. A consistent positive correlation between urinary HEL and DEHP metabolites was observed, but a consistent negative correlation between DEHP metabolites and selected cytokines was identified.Conclusion: The current study reveals a heightened risk of MEHHP and MEHP + MEHHP exposure in specific asthma subgroups, emphasizing its complex relationship with asthma. The observed negative correlation with cytokines suggests a new avenue for research, warranting robust evidence from epidemiological and animal studies.",

keywords = "Asthma phenotype, Comorbidities, DEHP, HEL, Inflammatory markers",

author = "Hsu, {Yuan Ting} and Wu, {Chao Chien} and Wang, {Chin Chou} and Sheu, {Chau Chyun} and Yang, {Yi Hsin} and Cheng, {Ming Yen} and Lai, {Ruay Sheng} and Leung, {Sum Yee} and Lin, {Chi Cheng} and Wei, {Yu Feng} and Lai, {Yung Fa} and Cheng, {Meng Hsuan} and Chen, {Huang Chi} and Yang, {Chih Jen} and Wang, {Chien Jen} and Liu, {Huei Ju} and Chen, {Hua Ling} and Hung, {Chih Hsing} and Lee, {Chon Lin} and Huang, {Ming Shyan} and Huang, {Shau Ku}",

note = "This work was supported, in part, by grants from National Health Research Institutes, Taiwan (EOPP10-014, EOSP07-014 and NHRI-102A1-PDCO-03010201) and Ministry of Health and Welfare, Taiwan (EODOH01), National Science Council (NSC 102-2314-B-037-052), Ministry of Science and Technology (MOST 103-2320-B-110-001), and Academia Sinica (BM-102021170), Taiwan. Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = mar,

day = "23",

doi = "10.1186/s12931-024-02764-8",

language = "English",

volume = "25",

journal = "Respiratory Research",

issn = "1465-9921",

publisher = "BioMed Central Ltd.",

number = "1",

}

Hsu, YT, Wu, CC, Wang, CC, Sheu, CC, Yang, YH, Cheng, MY, Lai, RS, Leung, SY, Lin, CC, Wei, YF, Lai, YF, Cheng, MH, Chen, HC, Yang, CJ, Wang, CJ, Liu, HJ, Chen, HL, Hung, CH, Lee, CL, Huang, MS & Huang, SK 2024, 'Increased di-(2-ethylhexyl) phthalate exposure poses a differential risk for adult asthma clusters', Respiratory Research, vol. 25, no. 1, 139. https://doi.org/10.1186/s12931-024-02764-8

TY - JOUR

T1 - Increased di-(2-ethylhexyl) phthalate exposure poses a differential risk for adult asthma clusters

AU - Hsu, Yuan Ting

AU - Wu, Chao Chien

AU - Wang, Chin Chou

AU - Sheu, Chau Chyun

AU - Yang, Yi Hsin

AU - Cheng, Ming Yen

AU - Lai, Ruay Sheng

AU - Leung, Sum Yee

AU - Lin, Chi Cheng

AU - Wei, Yu Feng

AU - Lai, Yung Fa

AU - Cheng, Meng Hsuan

AU - Chen, Huang Chi

AU - Yang, Chih Jen

AU - Wang, Chien Jen

AU - Liu, Huei Ju

AU - Chen, Hua Ling

AU - Hung, Chih Hsing

AU - Lee, Chon Lin

AU - Huang, Ming Shyan

AU - Huang, Shau Ku

N1 - This work was supported, in part, by grants from National Health Research Institutes, Taiwan (EOPP10-014, EOSP07-014 and NHRI-102A1-PDCO-03010201) and Ministry of Health and Welfare, Taiwan (EODOH01), National Science Council (NSC 102-2314-B-037-052), Ministry of Science and Technology (MOST 103-2320-B-110-001), and Academia Sinica (BM-102021170), Taiwan. Publisher Copyright: © The Author(s) 2024.

PY - 2024/3/23

Y1 - 2024/3/23

N2 - Background: DEHP, a common plasticizer known for its hormone-disrupting properties, has been associated with asthma. However, a significant proportion of adult asthma cases are “non-atopic”, lacking a clear etiology.Methods: In a case-control study conducted between 2011 and 2015, 365 individuals with current asthma and 235 healthy controls from Kaohsiung City were enrolled. The control group comprised individuals without asthma, Type 2 Diabetes Mellitus (T2DM), hypertension, or other respiratory/allergic conditions. The study leveraged asthma clusters (Clusters A to F) established in a prior investigation. Analysis involved the examination of urinary DEHP metabolites (MEHP and MEHHP), along with the assessment of oxidative stress, sphingolipid metabolites, and inflammatory biomarkers. Statistical analyses encompassed Spearman’s rank correlation coefficients, multiple logistic regression, and multinomial logistic regression. Results: Asthma clusters (E, D, C, F, A) exhibited significantly higher ORs of MEHHP exposures compared to the control group. When considering asthma-related comorbidities (T2DM, hypertension, or both), patients without comorbidities demonstrated significantly higher ORs of the sum of primary and secondary metabolites (MEHP + MEHHP) and MEHHP compared to those with asthma comorbidities. A consistent positive correlation between urinary HEL and DEHP metabolites was observed, but a consistent negative correlation between DEHP metabolites and selected cytokines was identified.Conclusion: The current study reveals a heightened risk of MEHHP and MEHP + MEHHP exposure in specific asthma subgroups, emphasizing its complex relationship with asthma. The observed negative correlation with cytokines suggests a new avenue for research, warranting robust evidence from epidemiological and animal studies.

AB - Background: DEHP, a common plasticizer known for its hormone-disrupting properties, has been associated with asthma. However, a significant proportion of adult asthma cases are “non-atopic”, lacking a clear etiology.Methods: In a case-control study conducted between 2011 and 2015, 365 individuals with current asthma and 235 healthy controls from Kaohsiung City were enrolled. The control group comprised individuals without asthma, Type 2 Diabetes Mellitus (T2DM), hypertension, or other respiratory/allergic conditions. The study leveraged asthma clusters (Clusters A to F) established in a prior investigation. Analysis involved the examination of urinary DEHP metabolites (MEHP and MEHHP), along with the assessment of oxidative stress, sphingolipid metabolites, and inflammatory biomarkers. Statistical analyses encompassed Spearman’s rank correlation coefficients, multiple logistic regression, and multinomial logistic regression. Results: Asthma clusters (E, D, C, F, A) exhibited significantly higher ORs of MEHHP exposures compared to the control group. When considering asthma-related comorbidities (T2DM, hypertension, or both), patients without comorbidities demonstrated significantly higher ORs of the sum of primary and secondary metabolites (MEHP + MEHHP) and MEHHP compared to those with asthma comorbidities. A consistent positive correlation between urinary HEL and DEHP metabolites was observed, but a consistent negative correlation between DEHP metabolites and selected cytokines was identified.Conclusion: The current study reveals a heightened risk of MEHHP and MEHP + MEHHP exposure in specific asthma subgroups, emphasizing its complex relationship with asthma. The observed negative correlation with cytokines suggests a new avenue for research, warranting robust evidence from epidemiological and animal studies.

KW - Asthma phenotype

KW - Comorbidities

KW - DEHP

KW - HEL

KW - Inflammatory markers

UR - https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-024-02764-8

UR - http://www.scopus.com/inward/record.url?scp=85188428899&partnerID=8YFLogxK

U2 - 10.1186/s12931-024-02764-8

DO - 10.1186/s12931-024-02764-8

M3 - Journal article

C2 - 38521900

AN - SCOPUS:85188428899

SN - 1465-9921

VL - 25

JO - Respiratory Research

JF - Respiratory Research

IS - 1

M1 - 139

ER -

Increased di-(2-ethylhexyl) phthalate exposure poses a differential risk for adult asthma clusters

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